Engineering Commons^™

Decision-Based Data Fusion Of Complementary Features For The Early Diagnosis Of Alzheimer's Disease, Metin Ahiskali

Theses and Dissertations

As the average life expectancy increases, particularly in developing countries, the prevalence of Alzheimer's disease (AD), which is the most common form of dementia worldwide, has increased dramatically. As there is no cure to stop or reverse the effects of AD, the early diagnosis and detection is of utmost concern. Recent pharmacological advances have shown the ability to slow the progression of AD; however, the efficacy of these treatments is dependent on the ability to detect the disease at the earliest stage possible. Many patients are limited to small community clinics, by geographic and/or financial constraints. Making diagnosis possible at …

Sensitivity Analysis And Calibration Of The Alligator Cracking Model In The Mechanistic-Empirical Pavement Design Guide Using Regional Data, Vivek Jha

Theses and Dissertations

The models used in the mechanistic-empirical pavement design guide (M-EPDG) were calibrated using the data from all across the United States. The alligator cracking model uses traffic, material and structural data along with local and global calibration factors to calculate the number of axles to failure and the damage index. Both of which are further used to calculate the fatigue cracking in the pavement with the help of regression coefficients and calibration constants. However, as these coefficients and constants were developed using the national database, the model might not predict the fatigue behavior of the pavement accurately for a particular …

The Extraction Of Cytochrome C And Dsred2 Into Reverse Micelles, Michelle Baker

Theses and Dissertations

Cytochrome c and DsRed2 were successfully extracted into reverse micelles by the contacting of an aqueous protein-containing phase with an organic phase. Two important properties that differentiate the extraction profiles of these proteins are pI and size. Cytochrome c is a relatively small, monomeric protein with a pI of 10.6. It was easily extracted into reverse micelles with the anionic surfactant AOT. DsRed2, however, is a large tetramer with a p1 of 6.3. It could not be extracted into AOT, but was extracted with the cationic surfactant CTAB, and with a wider error range than cytochrome c. CD data indicate …

Functional Near-Infrared Spectroscopy For Hb And Hbo₂ Detection Using Remote Sensing, Rane M. Pierson

Theses and Dissertations

The goal of the work presented in this thesis is to develop a wireless, near-infrared (NIR) imaging system to provide flexibility and functionality to clinicians and researchers who require monitoring of blood profusion to tissue, muscles, or the brain. The prototype device uses a single stimulus/detection unit composed of an Epitex NIR LED with three wavelength options: 730, 805, and 850 nm, and an OPT101 photodiode detector. The device can be used to detect changes in the levels of oxygenated and deoxygenated hemoglobin in the body by measuring the amounts of absorbed and backscattered light at the wavelength associated with …

Towards A Universal Ultra-Thin Fluorinated Diamond-Like Carbon Coating For Nanoimprint Lithography Imprinters, Ryan Winfield Fillman

Theses and Dissertations

Nanoimprint lithography (NIL) has proven to achieve arbitrary, nanoscale features, over large areas, without the use of costly step-and-repeat UV lithography tools. The fidelity of the imprinted pattern depends on the elimination of the adhesion between the imprinted polymer and the imprinter upon withdrawal of the imprinter. The plasma deposition of a layer of fluorinated diamond-like carbon (F-DLC) has proven to be a successful anti-adhesion layer but in the past has required an entire diamond-like carbon (DLC) substrate. The requirement that the imprinter be made of DLC limits the imprinter processing and can limit the capabilities of NIL. DLC films …

Integration Of Multiple Data Types In 3-D Immersive Virtual Reality (Vr) Environments, George Demetrius Lecakes Jr.

Theses and Dissertations

Intelligent sensors have begun to play a key part in the monitoring and maintenance of complex infrastructures. Sensors have the capability not only to provide raw data, but also provide "information" by indicating the reliability of the measurements. The effect of this added information is a voluminous increase in the total data that is gathered. If an operator is required to perceive the state of a complex system, novel methods must be developed for sifting through enormous data sets. Virtual reality (VR) platforms are proposed as ideal candidates for performing this task-- a virtual world will allow the user to …

Diesel Particulate Matter Quantification And Reduction Strategies For School Buses, David Martinez-Morett

Theses and Dissertations

This thesis evaluated the contributions of school bus self pollution from both the crankcase and the tailpipe emissions to in-cabin levels of fine and ultrafine particulate matter, and determined the effectiveness of commercially available retrofit technologies towards reducing levels of particulate matter inside the school bus passenger compartment. Mobile tests were conducted with a school bus powered by an International DT466E engine on an outdoor test track. Measurements of fine and ultrafine particle concentrations within the cabin of a school bus were performed with and without retrofit technologies.

The tests utilized a drive cycle using data from actual school bus …

Comparison Of Passive Cervical Spine Flexion In Children And Adults, Jami Saffioti

Theses and Dissertations

Head trauma is the most frequent injury sustained by children in car crashes, and the neck plays a key role in governing head kinematics during the crash. Pediatric anthropomorphic test devices (ATDs) are used to assess the risk of head injury, yet the pediatric ATD neck is a size-scaled model of the adult ATD neck, with no consideration for the tissue properties and morphological changes during human development. To help understand the effects of maturation on the changes in neck flexion biomechanics, this study compared the passive cervical spine flexion of children to adults in specific age groups (6-8, 9-12, …