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Full-Text Articles in Engineering
Two-Dimensional Layered Mos2 Biosensors Enable Highly Sensitive Detection Of Biomolecules, Joonhyung Lee, Piyush Dak, Yeonsung Lee, Heekyeong Park, Woong Choi, Muhammad Ashraful Alam, Sunkook Kim
Two-Dimensional Layered Mos2 Biosensors Enable Highly Sensitive Detection Of Biomolecules, Joonhyung Lee, Piyush Dak, Yeonsung Lee, Heekyeong Park, Woong Choi, Muhammad Ashraful Alam, Sunkook Kim
Birck and NCN Publications
We present a MoS2 biosensor to electrically detect prostate specific antigen (PSA) in a highly sensitive and label-free manner. Unlike previous MoS2-FET-based biosensors, the device configuration of our biosensors does not require a dielectric layer such as HfO2 due to the hydrophobicity of MoS2. Such an oxide-free operation improves sensitivity and simplifies sensor design. For a quantitative and selective detection of PSA antigen, anti-PSA antibody was immobilized on the sensor surface. Then, introduction of PSA antigen, into the anti-PSA immobilized sensor surface resulted in a lable-free immunoassary format. Measured off-state current of the device …
Nanoparticles For Multimodal In Vivo Imaging In Nanomedicine, Jaehong Key, James F. Leary
Nanoparticles For Multimodal In Vivo Imaging In Nanomedicine, Jaehong Key, James F. Leary
Birck and NCN Publications
While nanoparticles are usually designed for targeted drug delivery, they can also simultaneously provide diagnostic information by a variety of in vivo imaging methods. These diagnostic capabilities make use of specific properties of nanoparticle core materials. Near-infrared fluorescent probes provide optical detection of cells targeted by real-time nanoparticle-distribution studies within the organ compartments of live, anesthetized animals. By combining different imaging modalities, we can start with deep-body imaging by magnetic resonance imaging or computed tomography, and by using optical imaging, get down to the resolution required for real-time fluorescence-guided surgery.
Accuracy And Precision Of Computer-Simulated Tissue Temperatures In Individual Human Intracranial Tumours Treated With Interstitial Hyperthermia, J A. Deford, Charles F. Babbs, U H. Patel, N E. Fearnot, J A. Marchosky, C J. Moran
Accuracy And Precision Of Computer-Simulated Tissue Temperatures In Individual Human Intracranial Tumours Treated With Interstitial Hyperthermia, J A. Deford, Charles F. Babbs, U H. Patel, N E. Fearnot, J A. Marchosky, C J. Moran
Weldon School of Biomedical Engineering Faculty Publications
Accurate knowledge of tissue temperature is necessary for effective delivery of clinical hyperthermia in the treatment of malignant tumours. This report compares computer-predicted versus measured intratumoral temperatures in 11 human subjects with intracranial tumours, treated with a conceptually simple 'conductive' interstitial hyperthermia system. Interstitial hyperthermia was achieved by the use of parallel arrays of implanted, electrically heated catheters. The tissue was warmed by thermal conduction and blood convection. Simulation of intratumoral temperatures was achieved by solving a modified bioheat transfer equation on a digital computer using a finite difference method. Comparison of intratumoral temperatures from simulations and measured values differed …
Use Of Combined Systemic Hypothermia And Local Heat Treatment To Enhance Temperature Differences Between Tumor And Normal Tissues, Charles F. Babbs, William D. Voorhees Iii, Robert R. Clark, David P. Dewitt
Use Of Combined Systemic Hypothermia And Local Heat Treatment To Enhance Temperature Differences Between Tumor And Normal Tissues, Charles F. Babbs, William D. Voorhees Iii, Robert R. Clark, David P. Dewitt
Weldon School of Biomedical Engineering Faculty Publications
The feasibility of combining local heat treatment with wholebody hypothermia in an effort to improve therapeutic gain was assessed. Superficial, non perfused phantom tumors were fashioned in eight anesthetized mongrel dogs by transplantation of the spleen from the abdomen to a subcutaneous site on the hind limb. After pretreatment of the animal with the vasodilator hydralazine (0.5 mg/kg, IV) to enhance normal tissue perfusion, the spleen implant was heated with a 2450-MHz microwave diathermy apparatus, first with the animal's core body temperature in the normal range (39°C) and then after the animal had been packed in ice to reduce core …
Biology Of Local Heat Therapy For Cancer, Charles F. Babbs
Biology Of Local Heat Therapy For Cancer, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Successful cancer therapy must selectively destroy tumor tissue while sparing the host's normal tissues. Local heat treatment can have such a selective effect because abnormalities in tumor blood vessels supply less oxygen to heat-stressed tumor cells and are less efficient in cooling tumor tissue by blood perfusion.
Theoretical Feasibility Of Vasodilator-Enhanced Local Tumor Heating, Charles F. Babbs, David P. Dewitt, William D. Voorhees, Janet S. Mccaw, Rosanna C. Chan
Theoretical Feasibility Of Vasodilator-Enhanced Local Tumor Heating, Charles F. Babbs, David P. Dewitt, William D. Voorhees, Janet S. Mccaw, Rosanna C. Chan
Weldon School of Biomedical Engineering Faculty Publications
Normal arterioles, in contrast to the abnormal microvasculature of many solid tumors, provide a target for selective drug action that can enhance local heat treatment of the tumors. Measurements of tissue blood flow with radioactive microspheres and estimates of changes in blood flow with thermal clearance methods revealed that vasodilator drugs either decreased or did not alter blood flow in hamster melanoma, rat hepatoma, and canine transmissible venereal tumor, while increasing perfusion in adjacent normal tissues 2 to 4-fold. Solutions of the bio-heat transfer equation, which take into account such selective effects of vasodilators on blood flow in normal tissues, …
Physical Principles Of Local Heat Therapy For Cancer, Charles F. Babbs, David P. Dewitt
Physical Principles Of Local Heat Therapy For Cancer, Charles F. Babbs, David P. Dewitt
Weldon School of Biomedical Engineering Faculty Publications
Local hyperthermia therapy for cancer can produce selective heating of solid tumors on the basis of known physical laws. If energy is deposited in the general region of the tumor, temperature tends to develop in the tumor higher than that in surrounding normal tissues. The goal of therapy is to achieve cytotoxic temperature elevations in the tumor for an adequate period of time, without damaging nearby normal tissues. Several modalities exist for local heat treatment, of which radiofrequency and ultrasound offer the most promise for controlled, localized heating at depth. A paucity of blood flow in the tumor compared to …