Engineering Commons^™

A Quasi-Monte Carlo Solver For Thermal Radiation In Participating Media, Joseph Farmer, Somesh Roy

Mechanical Engineering Faculty Research and Publications

The Monte Carlo (MC) method is the most accurate method for resolving radiative heat transfer in participating media. However, it is also computationally prohibitive in large-scale simulations. To alleviate this, this study proposes a quasi-Monte Carlo (QMC) method for thermal radiation in participating media with a focus on combustion-related problems. The QMC method employs low-discrepancy sequences (LDS) in place of the traditional random numbers. Three different low-discrepancy sequences – Sobol, Halton, and Niederreiter – were examined as part of this work. The developed QMC method was first validated against analytical solutions of radiative heat transfer in several one-dimensional configurations. Then …

An Efficient Monte Carlo-Based Solver For Thermal Radiation In Participating Media, Joseph Farmer, Somesh Roy

Mechanical Engineering Faculty Research and Publications

Monte Carlo-based solvers, while well-suited for accurate calculation of complex thermal radiation transport problems in participating media, are often deemed computationally unattractive for use in the solution of real-world problems. The main disadvantage of Monte Carlo (MC) solvers is their slow convergence rate and relatively high computational cost. This work presents a novel approach based on a low-discrepancy sequence (LDS) and is proposed for reducing the error bound of a Monte Carlo-based radiation solver. Sobols sequence – an LDS generated with a bit-by-bit exclusive-or operator – is used to develop a quasi-Monte Carlo (QMC) solver for thermal radiation in this …

Mitigation Of Radiation Induced Pulmonary Vascular Injury By Delayed Treatment With Captopril, Robert C. Molthen, Qingping Wu, Brian L. Fish, John E. Moulder, Elizabeth R. Jacobs, Meetha M. Medhora

Biomedical Engineering Faculty Research and Publications

Background and Objective: A single dose of 10 Gy radiation to the thorax of rats results in decreased total lung angiotensin-converting enzyme (ACE) activity, pulmonary artery distensibility and distal vascular density while increasing pulmonary vascular resistance (PVR) at 2 months post-exposure. In this study, we evaluate the potential of a renin-angiotensin system (RAS) modulator, the ACE inhibitor captopril, to mitigate this pulmonary vascular damage.

Methods: Rats exposed to 10 Gy thorax only irradiation and age-matched controls were studied 2 months after exposure, during the development of radiation pneumonitis. Rats were treated, either immediately or 2 weeks after radiation exposure, with …

Vascular Injury After Whole Thoracic X-Ray Irradiation In The Rat, S. N. Ghosh, Q. Wu, M. Mäder, B. L. Fish, John E. Moulder, Elizabeth R. Jacobs, Meetha Medhora, Robert C. Molthen

Biomedical Engineering Faculty Research and Publications

Purpose

To study vascular injury after whole thoracic irradiation with single sublethal doses of X-rays in the rat and to develop markers that might predict the severity of injury.

Methods and Materials

Rats that received 5- or 10-Gy thorax-only irradiation and age-matched controls were studied at 3 days, 2 weeks, and 1, 2, 5, and 12 months. Several pulmonary vascular parameters were evaluated, including hemodynamics, vessel density, total lung angiotensin-converting enzyme activity, and right ventricular hypertrophy.

Results

By 1 month, the rats in the 10-Gy group had pulmonary vascular dropout, right ventricular hypertrophy, increased pulmonary vascular resistance, increased dry lung …

Imaging Radiation Pneumonitis In A Rat Model Of A Radiological Terrorism Incident, Robert C. Molthen, Qingping Wu, Gary S. Krenz, Meetha Medhora, Elizabeth R. Jacobs, John E. Moulder

Biomedical Engineering Faculty Research and Publications

We have developed a rat model of single, sub-lethal thoracic irradiation. Our irradiation protocol is considered representative of exposures near the detonation site of a dirty bomb or small nuclear device. The model is being used to investigate techniques for identifying, triaging and treating possible victims. In addition to physiological markers of right ventricular hypertrophy, pulmonary vascular resistance, and arterial distensibility, we present two methods for quantifying microvascular density. We used methods including microfocal X-ray imaging to investigate changes in lung structure/function resulting from radiation exposure. Radiation pneumonitis is a complication in subjects receiving thoracic irradiation. A radiographic hallmark of …