Engineering Commons^™

Effect Of Tendon Vibration On Hemiparetic Arm Stability In Unstable Workspaces, Megan O. Conrad, Bani Gadhoke, Robert A. Scheidt, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

Sensory stimulation of wrist musculature can enhance stability in the proximal arm and may be a useful therapy aimed at improving arm control post-stroke. Specifically, our prior research indicates tendon vibration can enhance stability during point-to-point arm movements and in tracking tasks. The goal of the present study was to investigate the influence of forearm tendon vibration on endpoint stability, measured at the hand, immediately following forward arm movements in an unstable environment. Both proximal and distal workspaces were tested. Ten hemiparetic stroke subjects and 5 healthy controls made forward arm movements while grasping the handle of a two-joint robotic …

Plasmonic Field Confinement For Separate Absorption-Multiplication In Ingaas Nanopillar Avalanche Photodiodes, Alan C. Farrell, Pradeep Senanayake, Chung-Hong Hung, George El-Howayek, Abhejit Rajagopal, Marc Currie, Majeed M. Hayat, Diana L. Huffaker

Electrical and Computer Engineering Faculty Research and Publications

Avalanche photodiodes (APDs) are essential components in quantum key distribution systems and active imaging systems requiring both ultrafast response time to measure photon time of flight and high gain to detect low photon flux. The internal gain of an APD can improve system signal-to-noise ratio (SNR). Excess noise is typically kept low through the selection of material with intrinsically low excess noise, using separate-absorption-multiplication (SAM) heterostructures, or taking advantage of the dead-space effect using thin multiplication regions. In this work we demonstrate the first measurement of excess noise and gain-bandwidth product in III–V nanopillars exhibiting substantially lower excess noise factors …

Retinal Architecture In ​Rgs9- And ​R9ap-Associated Retinal Dysfunction (Bradyopsia), Rupert W. Strauss, Adam M. Dubis, Robert F. Cooper, Rola Ba-Abbad, Anthony T. Moore, Andrew R. Webster, Alfredo Dubra, Joseph Carroll, Michel Michaelides

Biomedical Engineering Faculty Research and Publications

Purpose

To characterize photoreceptor structure and mosaic integrity in subjects with RGS9- and R9AP-associated retinal dysfunction (bradyopsia) and compare to previous observations in other cone dysfunction disorders such as oligocone trichromacy.

Design

Observational case series.

Methods

setting: Moorfields Eye Hospital (United Kingdom) and Medical College Wisconsin (USA). study population: Six eyes of 3 subjects with disease-causing variants in RGS9 or R9AP. main outcome measures: Detailed retinal imaging using spectral-domain optical coherence tomography and confocal adaptive-optics scanning light ophthalmoscopy.

Results

Cone density at 100 μm from foveal center ranged from 123 132 cones/mm²to 140 013 cones/mm^{2 …}

Biochar From Pyrolysis Of Biosolids For Nutrient Adsorption And Turfgrass Cultivation, Daniel Elliott Carey, Patrick J. Mcnamara, Daniel Zitomer

Civil and Environmental Engineering Faculty Research and Publications

At water resource recovery facilities, nutrient removal is often required and energy recovery is an ever-increasing goal. Pyrolysis may be a sustainable process for handling wastewater biosolids because energy can be recovered in the py-gas and py-oil. Additionally, the biochar produced has value as a soil conditioner. The objective of this work was to determine if biochar could be used to adsorb ammonia from biosolids filtrate and subsequently be applied as a soil conditioner to improve grass growth. The maximum carrying capacity of base modified biochar for NH₃−N was 5.3 mg/g. Biochar containing adsorbed ammonium and potassium was …

Comments On “The Principal Axes Decomposition Of Spatial Stiffness Matrices”, Shuguang Huang, Joseph M. Schimmels

Mechanical Engineering Faculty Research and Publications

A significant amount of research has been directed toward developing a more intuitive appreciation of spatial elastic behavior. Results of these analyses have been described in terms of behavior decompositions and in terms of behavior centers. In a recent paper entitled “The Principal Axes Decomposition of Spatial Stiffness Matrices” by Chen et al. (IEEE Trans. Robot., vol. 31, no. 1, pp. 191-207), a decomposition of spatial stiffness was presented, and centers of stiffness and compliance were identified. The results presented in the paper have substantial overlap with previously published results and redefine previously used terms. The objective of this communication …

Increased Lower Limb Spasticity But Not Strength Or Function Following A Single-Dose Serotonin Reuptake Inhibitor In Chronic Stroke, Krishnaj Gourab, Brian D. Schmit, T. George Hornby

Biomedical Engineering Faculty Research and Publications

Objective: To investigate the effects of single doses of a selective serotonin reuptake inhibitor (SSRI) on lower limb voluntary and reflex function in individuals with chronic stroke.

Design: Double-blind, randomized, placebo-controlled crossover trial.

Setting: Outpatient research setting.

Participants: Individuals (N=10; 7 men; mean age ± SD, 57±10y) with poststroke hemiplegia of >1 year duration who completed all assessments.

Interventions: Patients were assessed before and 5 hours after single-dose, overencapsulated 10-mg doses of escitalopram (SSRI) or placebo, with 1 week between conditions.

Main Outcome Measures: Primary assessments included maximal ankle and knee isometric strength, and velocity-dependent (30°/s–120°/s) plantarflexor stretch reflexes under …

Ecohydrological Controls On Grass And Shrub Above-Ground Net Primary Productivity In A Seasonally Dry Climate, Anthony J. Parolari, Michael L. Goulden, Rafael L. Bras

Civil and Environmental Engineering Faculty Research and Publications

Seasonally dry, water‐limited regions are often co‐dominated by distinct herbaceous and woody plant communities with contrasting ecohydrological properties. We investigated the shape of the above‐ground net primary productivity (ANPP) response to annual precipitation (P_a) for adjacent grassland and shrubland ecosystems in Southern California, with the goal of understanding the role of these ecohydrological properties on ecosystem function. Our synthesis of observations and modelling demonstrates grassland and shrubland exhibit distinct ANPP‐P_a responses that correspond with characteristics of the long‐term P_a distribution and mean water balance fluxes. For annual grassland, no ANPP occurs below a ‘precipitation …

Toward Higher-Order Mass Detection: Influence Of An Adsorbate’S Rotational Inertia And Eccentricity On The Resonant Response Of A Bernoulli-Euler Cantilever Beam, Stephen M. Heinrich, Isabelle Dufour

Civil and Environmental Engineering Faculty Research and Publications

In this paper a new theoretical model is derived, the results of which permit a detailed examination of how the resonant characteristics of a cantilever are influenced by a particle (adsorbate) attached at an arbitrary position along the beam’s length. Unlike most previous work, the particle need not be small in mass or dimension relative to the beam, and the adsorbate’s geometric characteristics are incorporated into the model via its rotational inertia and eccentricity relative to the beam axis. For the special case in which the adsorbate’s (translational) mass is indeed small, an analytical solution is obtained for the particle-induced …

Stochastic Rainfall-Runoff Model With Explicit Soil Moisture Dynamics, Mark Bartlett, E. Daly, Jeffrey Mcdonnell, Anthony J. Parolari, Amilcare Porporato

Civil and Environmental Engineering Faculty Research and Publications

Stream runoff is perhaps the most poorly represented process in ecohydrological stochastic soil moisture models. Here we present a rainfall-runoff model with a new stochastic description of runoff linked to soil moisture dynamics. We describe the rainfall-runoff system as the joint probability density function (PDF) of rainfall, soil moisture and runoff forced by random, instantaneous jumps of rainfall. We develop a master equation for the soil moisture PDF that accounts explicitly for a general state-dependent rainfall-runoff transformation. This framework is then used to derive the joint rainfall-runoff and soil moisture-runoff PDFs. Runoff is initiated by a soil moisture threshold and …

Forecasting Design Day Demand Using Extremal Quantile Regression, David Joseph Kaftan, Jarrett L. Smalley, George F. Corliss, Ronald H. Brown, Richard James Povinelli

Electrical and Computer Engineering Faculty Research and Publications

Extreme events occur rarely, making them difficult to predict. Extreme cold events strain natural gas systems to their limits. Natural gas distribution companies need to be prepared to satisfy demand on any given day that is at or warmer than an extreme cold threshold. The hypothetical day with temperature at this threshold is called the Design Day. To guarantee Design Day demand is satisfied, distribution companies need to determine the demand that is unlikely to be exceeded on the Design Day.

We approach determining this demand as an extremal quantile regression problem. We review current methods for extremal quantile regression. …

Effect Of Imperceptible Vibratory Noise Applied To Wrist Skin On Fingertip Touch Evoked Potentials – An Eeg Study, Na Jin Seo, Kishor Lakshminarayanan, Leonardo Bonilha, Abigail W. Lauer, Brian D. Schmit

Biomedical Engineering Faculty Research and Publications

Random vibration applied to skin can change the sense of touch. Specifically, low amplitude white-noise vibration can improve fingertip touch perception. In fact, fingertip touch sensation can improve even when imperceptible random vibration is applied to other remote upper extremity areas such as wrist, dorsum of the hand, or forearm. As such, vibration can be used to manipulate sensory feedback and improve dexterity, particularly during neurological rehabilitation. Nonetheless, the neurological bases for remote vibration enhanced sensory feedback are yet poorly understood. This study examined how imperceptible random vibration applied to the wrist changes cortical activity for fingertip sensation. We measured …

Detection Of Acute Nervous System Injury With Advanced Diffusion-Weighted Mri: A Simulation And Sensitivity Analysis, Nathan P. Skinner, Shekar N. Kurpad, Brian Schmit, Matthew D. Budde

Biomedical Engineering Faculty Research and Publications

Diffusion-weighted imaging (DWI) is a powerful tool to investigate the microscopic structure of the central nervous system (CNS). Diffusion tensor imaging (DTI), a common model of the DWI signal, has a demonstrated sensitivity to detect microscopic changes as a result of injury or disease. However, DTI and other similar models have inherent limitations that reduce their specificity for certain pathological features, particularly in tissues with complex fiber arrangements. Methods such as double pulsed field gradient (dPFG) and q-vector magic angle spinning (qMAS) have been proposed to specifically probe the underlying microscopic anisotropy without interference from the macroscopic tissue organization. …

Computational Replication Of The Patient-Specific Stenting Procedure For Coronary Artery Bifurcations: From Oct And Ct Imaging To Structural And Hemodynamics Analyses, Claudio Chiastra, Wei Wu, Benjamin Dickerhoff, Ali Aleiou, Gabriele Dubini, Hiromasa Otake, Francesco Migliavacca, John F. Ladisa Jr.

Biomedical Engineering Faculty Research and Publications

The optimal stenting technique for coronary artery bifurcations is still debated. With additional advances computational simulations can soon be used to compare stent designs or strategies based on verified structural and hemodynamics results in order to identify the optimal solution for each individual’s anatomy. In this study, patient-specific simulations of stent deployment were performed for 2 cases to replicate the complete procedure conducted by interventional cardiologists. Subsequent computational fluid dynamics (CFD) analyses were conducted to quantify hemodynamic quantities linked to restenosis.

Patient-specific pre-operative models of coronary bifurcations were reconstructed from CT angiography and optical coherence tomography (OCT). Plaque location and …

Ion Exchange-Precipitation For Nutrient Recovery From Dilute Wastewater, A. T. Williams, Daniel Zitomer, Brooke K. Mayer

Civil and Environmental Engineering Faculty Research and Publications

Regulated phosphorus (P) and nitrogen (N) discharges and the cost of fertilizer provide economic drivers for nutrient removal and recovery from wastewater. This study used ion exchange (IX) in dilute (domestic) wastewater to concentrate nutrients with subsequent recovery by struvite precipitation. This is the first tertiary wastewater treatment study directly comparing P removal using a range of Fe, Cu, and Al-based media followed by clinoptilolite IX columns for N removal and precipitation using the combined regenerants. Phosphate removal prior to breakthrough was 0.5–2.0 g P L_media⁻¹, providing effluent concentrations −1 PO₄-P and −1 NH_{4 …}

Quantifying Cross-Scatter Contamination In Biplane Fluoroscopy Motion Analysis Systems, Janelle A. Cross, Ben Mchenry, Taly Gilat-Schmidt

Biomedical Engineering Faculty Research and Publications

Biplane fluoroscopy is used for dynamic in vivo three-dimensional motion analysis of various joints of the body. Cross-scatter between the two fluoroscopy systems may limit tracking accuracy. This study measured the magnitude and effects of cross-scatter in biplane fluoroscopic images. Four cylindrical phantoms of 4-, 6-, 8-, and 10-in. diameter were imaged at varying kVp levels to determine the cross-scatter fraction and contrast-to-noise ratio (CNR). Monte Carlo simulations quantified the effect of the gantry angle on the cross-scatter fraction. A cadaver foot with implanted beads was also imaged. The effect of cross-scatter on marker-based tracking accuracy was investigated. Results demonstrated …

Alagebrium Inhibits Neointimal Hyperplasia And Restores Distributions Of Wall Shear Stress By Reducing Downstream Vascular Resistance In Obese And Diabetic Rats, Hongfeng Wang, Dorothee Weihrauch, Judy R. Kersten, Jeffrey M. Toth, Anthony G. Passerini, Anita Rajamani, Sonja Schrepfer, John F. Ladisa Jr.

Biomedical Engineering Faculty Research and Publications

Mechanisms of restenosis in type 2 diabetes mellitus (T2DM) are incompletely elucidated, but advanced glycation end-products (AGEs)-induced vascular remodeling likely contributes. We tested the hypothesis that AGEs-related collagen cross-linking (ARCC) leads to increased downstream vascular resistance (DVR), and altered in-stent hemodynamics, thereby promoting neointimal hyperplasia (NH) in T2DM. We proposed that decreasing ARCC with ALT-711 (Alagebrium) would mitigate this response. Abdominal aortic stents were implanted in Zucker lean (ZL), obese (ZO), and diabetic (ZD) rats. Blood flow, vessel diameter, and wall shear stress (WSS) were calculated after 21 days, and NH was quantified. Arterial segments (aorta, carotid, iliac, femoral, arterioles) …

Fellow Eye Changes In Patients With Nonischemic Central Retinal Vein Occlusion: Assessment Of Perfused Foveal Microvascular Density And Identification Of Nonperfused Capillaries, Alexander Pinhas, Michael Dubow, Nishit Shah, Eric Cheang, Chun L. Liu, Moataz Razeen, Alexander Gan, Rishard Weitz, Yusufu N. Sulai, Toco Y.P. Chui, Alfredo Dubra, Richard B. Rosen

Biomedical Engineering Faculty Research and Publications

Purpose: Eyes fellow to nonischemic central retinal vein occlusion (CRVO) were examined for abnormalities, which might explain their increased risk for future occlusion, using adaptive optics scanning light ophthalmoscope fluorescein angiography.

Methods: Adaptive optics scanning light ophthalmoscope fluorescein angiography foveal microvascular densities were calculated. Nonperfused capillaries adjacent to the foveal avascular zone were identified. Spectral domain optical coherence tomography, ultrawide field fluorescein angiographies, and microperimetry were also performed.

Results: Ten fellow eyes of nine nonischemic CRVO and 1 nonischemic hemi-CRVO subjects and four affected eyes of three nonischemic CRVO and one nonischemic hemi-CRVO subjects were imaged. Ninety percent of fellow …

Biomechanics Of Pediatric Manual Wheelchair Mobility, Brooke A. Slavens, Alyssa J. Schnorenberg, Christine M. Aurit, Sergey Tarima, Lawrence C. Vogel, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Currently, there is limited research of the biomechanics of pediatric manual wheelchair mobility. Specifically, the biomechanics of functional tasks and their relationship to joint pain and health is not well understood. To contribute to this knowledge gap, a quantitative rehabilitation approach was applied for characterizing upper extremity biomechanics of manual wheelchair mobility in children and adolescents during propulsion, starting, and stopping tasks. A Vicon motion analysis system captured movement, while a SmartWheel simultaneously collected three-dimensional forces and moments occurring at the handrim. A custom pediatric inverse dynamics model was used to evaluate three-dimensional upper extremity joint motions, forces, and moments …

Error Probabilities For Optical Receivers That Employ Dynamically Biased Avalanche Photodiodes, Georges El-Howayek, Majeed M. Hayat

Electrical and Computer Engineering Faculty Research and Publications

A novel theory was recently reported for the avalanche multiplication process in avalanche photodiodes (APDs) under dynamic reverse-biasing conditions. It has been shown theoretically that the bit-synchronized, periodic modulation of the electric field in the multiplication region can offer improvements in the gain-bandwidth product by reducing intersymbol interference in optical receivers. This paper reports a rigorous formulation of the sensitivity of optical receivers that employ dynamically biased APDs. To enable the sensitivity analysis, a recurrence theory is developed to calculate the joint probability distribution function (PDF) of the stochastic gain and avalanche buildup time in APDs that are operated under …

Integrating Distributed Sources Of Information For Construction Cost Estimating Using Semantic Web And Semantic Web Service Technologies, Mehrdad Niknam, Saeed Karshenas

Civil and Environmental Engineering Faculty Research and Publications

A construction project requires collaboration of several organizations such as owner, designer, contractor, and material supplier organizations. These organizations need to exchange information to enhance their teamwork. Understanding the information received from other organizations requires specialized human resources. Construction cost estimating is one of the processes that requires information from several sources including a building information model (BIM) created by designers, estimating assembly and work item information maintained by contractors, and construction material cost data provided by material suppliers. Currently, it is not easy to integrate the information necessary for cost estimating over the Internet.

This paper discusses a new …

Opportunities To Identify Unmet Needs Outside Of The Operating Room, Jay R. Goldberg

Biomedical Engineering Faculty Research and Publications

The ability to identify unmet needs and new product opportunities is an important skill for biomedical engineering students planning a career in the medical device industry. Most biomedical engineering graduates will work in industry where many projects will not be defined for them. They will need to work with physicians, surgeons, nurses, clinical engineers, and other users of medical technology to identify problems and unmet needs and will work closely with marketing, sales, and other personnel to identify new product development opportunities. Students will be better prepared for careers involving the development of new medical devices if they are able …

Impaired Regulation Post-Stroke Of Motor Unit Firing Behavior During Volitional Relaxation Of Knee Extensor Torque Assessed Using High Density Surface Emg Decomposition, Spencer A. Murphy, Reivian Berrios, P. Andrew Nelson, Francesco Negro, Dario Farina, Brian D. Schmit, Allison Hyngstrom

Physical Therapy Faculty Research and Publications

The purpose of this study was to use high density surface EMG recordings to quantify stroke-related abnormalities in motor unit firing behavior during repeated sub-maximal knee extensor contractions. A high density surface EMG system (sEMG) was used to record and extract single motor unit firing behavior in the vastus lateralis muscle of 6 individuals with chronic stroke and 8 controls during repeated sub-maximal isometric knee extension contractions. Paretic motor unit firing rates were increased with subsequent contractions (6.19±0.35 pps vs 7.89±0.66 pps, P

Stretch‐Induced Increase In Cardiac Contractility Is Independent Of Myocyte Ca2+ While Block Of Stretch Channels By Streptomycin Improves Contractility After Ischemic Stunning, Samhita S. Rhodes, Amadou Ks Camara, Mohammed Aldakkak, James S. Heisner, David F. Stowe

Biomedical Engineering Faculty Research and Publications

Stretching the cardiac left ventricle (LV) enhances contractility but its effect on myoplasmic [Ca²⁺] is controversial. We measured LV pressure (LVP) and [Ca²⁺] as a function of intra-LV stretch in guinea pig intact hearts before and after 15 min global stunning ± perfusion with streptomycin (STM), a stretch activated channel blocker. LV wall [Ca²⁺] was measured by indo-1 fluorescence and LVP by a saline-filled latex balloon inflated in 50 μL steps to stretch the LV. We implemented a mathematical model to interpret crossbridge dynamics and myofilament Ca²⁺ responsiveness from the instantaneous relationship between …

Survivable Cloud Network Mapping For Disaster Recovery Support, Feng Gu, Khaled B. Shaban, Nasir Ghani, Samee Khan, Mahshid R. Naeini, Majeed M. Hayat, Chadi Assi

Electrical and Computer Engineering Faculty Research and Publications

Network virtualization is a key provision for improving the scalability and reliability of cloud computing services. In recent years, various mapping schemes have been developed to reserve VN resources over substrate networks. However, many cloud providers are very concerned about improving service reliability under catastrophic disaster conditions yielding multiple system failures. To address this challenge, this work presents a novel failure region-disjoint VN mapping scheme to improve VN mapping survivability. The problem is first formulated as a mixed integer linear programming problem and then two heuristic solutions are proposed to compute a pair of failure region-disjoint VN mappings. The solution …

Validation Of A Finite Element Model Of The Humerus For Fracture Risk Assessment During Assisted Ambulation, Jessica M. Fritz, Prateek Grover, Nicole M. Grosland, Carolyne Albert, Linda M. Mcgrady, Mei Wang, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Finite Element Assessment Of Pediatric Femoral Response To Loading During Ambulation: Normal Vs. Osteogenesis Imperfecta (Oi) Bone, Jessica M. Fritz, Carolyne Albert, Nicole M. Grosland, Peter A. Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

No abstract provided.

Using Swing Resistance And Assistance To Improve Gait Symmetry In Individuals Post-Stroke, Sheng-Che Yen, Brian D. Schmit, Ming Wu

Biomedical Engineering Faculty Research and Publications

A major characteristic of hemiplegic gait observed in individuals post-stroke is spatial and temporal asymmetry, which may increase energy expenditure and the risk of falls. The purpose of this study was to examine the effects of swing resistance/assistance applied to the affected leg on gait symmetry in individuals post-stroke. We recruited 10 subjects with chronic stroke who demonstrated a shorter step length with their affected leg in comparison to the non-affected leg during walking. They participated in two test sessions for swing resistance and swing assistance, respectively. During the adaptation period, subjects counteracted the step length deviation caused by the …

Improved Terahertz Modulation Using Germanium Telluride (Gete) Chalcogenide Thin Films, A. H. Gwin, C. H. Kodama, T. Laurvick, Ronald A. Coutu Jr., P. F. Taday

Electrical and Computer Engineering Faculty Research and Publications

We demonstrate improved terahertz (THz) modulation using thermally crystallized germanium telluride (GeTe) thin films. GeTe is a chalcogenidematerial that exhibits a nonvolatile, amorphous to crystalline phase change at approximately 200 °C, as well as six orders of magnitude decreased electrical resistivity. In this study, amorphous GeTe thin filmswere sputtered on sapphire substrates and then tested using THz time-domain spectroscopy (THz-TDS). The test samples, heated in-situ while collecting THz-TDS measurements, exhibited a gradual absorbance increase, an abrupt nonvolatile reduction at the transition temperature, followed by another gradual increase in absorbance. The transition temperature was verified by conducting similar thermal tests while …

Establishing The Relative Merits Of Interior And Spoke-Type Permanent-Magnet Machines With Ferrite Or Ndfeb Through Systematic Design Optimization, Peng Zhang, Gennadi Y. Sizov, Dan M. Ionel, Nabeel Demerdash

Electrical and Computer Engineering Faculty Research and Publications

In this paper, a multiobjective design optimization method combining design-of-experiments techniques and differential-evolution algorithms is presented. The method was implemented and utilized in order to provide practical engineering insights for the optimal design of interior and spoke-type permanent-magnet machines. Two combinations with 12 slots and 8 poles and 12 slots and 10 poles, respectively, have been studied in conjunction with rare-earth neodymium-iron-boron (NdFeB) and ferrites. As part of the optimization process, a computationally efficient finite-element electromagnetic analysis was employed for estimating the performance of thousands of candidate designs. Three optimization objectives were concurrently considered for minimum total material cost, power …

The Doomsday Equation And 50 Years Beyond: New Perspectives On The Human-Water System, Anthony J. Parolari, Gabriel Katul, Amilcare Porporato

Civil and Environmental Engineering Faculty Research and Publications

In 1960, von Foerster et al. humorously predicted an abrupt transition in human population growth to occur in the mid‐21st century. Their so‐called ‘Doomsday’ emerged from either progressive degradation of a finite resource or faster‐than‐exponential growth of an increasingly resource‐use efficient population, though what constitutes this resource was not made explicit. At present, few dispute the claim that water is the most fundamental resource to sustainable human population growth. Multiple lines of evidence demonstrate that the global water system exhibits nontrivial dynamics linked to similar patterns in population growth. Projections of the global water system range from a finite carrying …