Engineering Commons^™

Intention Tremor And Deficits Of Sensory Feedback Control In Multiple Sclerosis: A Pilot Study, Megan Heenan, Robert A. Scheidt, Douglas Woo, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Background

Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor control in the brain. Here we describe a systems-level approach to characterizing sensorimotor control and use this approach to examine how sensory and motor processes are differentially impacted by MS.

Methods

Eight subjects with MS and eight age- and gender-matched healthy control subjects performed visually-guided flexion/extension tasks about the elbow to characterize a sensory feedback control model that …

Reversible Blockade Of Complex I Or Inhibition Of Pkcβ Reduces Activation And Mitochondria Translocation Of P66Shc To Preserve Cardiac Function After Ischemia, Meiying Yang, David F. Stowe, Kenechukwu B. Udoh, James S. Heisner, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Aim

Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66^Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H₂O₂. Ablation of p66^Shc protects against IR injury, but it is unknown if and when p66^Shc is activated during cardiac ischemia and/or reperfusion and if attenuating complex I electron transfer or deactivating PKCβ alters p66^Shc activation during IR is associated with cardioprotection.

Methods

Isolated guinea pig hearts were perfused and subjected to increasing periods …

Homogenous Ensemble Phonotactic Language Recognition Based On Svm Supervector Reconstruction, Wei-Wei Liu, Wei-Qiang Zhang, Michael T. Johnson, Jia Liu

Electrical and Computer Engineering Faculty Research and Publications

Currently, acoustic spoken language recognition (SLR) and phonotactic SLR systems are widely used language recognition systems. To achieve better performance, researchers combine multiple subsystems with the results often much better than a single SLR system. Phonotactic SLR subsystems may vary in the acoustic features vectors or include multiple language-specific phone recognizers and different acoustic models. These methods achieve good performance but usually compute at high computational cost. In this paper, a new diversification for phonotactic language recognition systems is proposed using vector space models by support vector machine (SVM) supervector reconstruction (SSR). In this architecture, the subsystems share the same …

Disinfection Byproduct Formation Resulting From Settled, Filtered, And Finished Water Treated By Titanium Dioxide Photocatalysis, Brooke K. Mayer, Erin Daugherty, Morteza Abbaszadegan

Civil and Environmental Engineering Faculty Research and Publications

This study evaluated strategies targeting disinfection byproduct (DBP) mitigation using TiO₂ photocatalysis with varying influent water quality. A Purifics Photo-CAT Lab reactor was used to assess total trihalomethane (TTHM) and haloacetic acid (HAA) formation as a function of photocatalytic treatment using water from a conventional coagulation/flocculation/sedimentation process, granular activated carbon filtration, and a DBP hot spot in the water distribution system. Regardless of influent water quality, photocatalysis reduced DBP precursors; however, low-energy limited photocatalysis (m⁻³), exacerbated the production of TTHMs and HAA5s beyond initial levels. Accordingly, limited photocatalysis is not a suitable option when TTHMs and HAA5s …

A Microfluidic Device For Thermal Particle Detection, Ashwin Kumar Vutha, Benyamin Davaji, Chung-Hoon Lee, Glenn M. Walker

Electrical and Computer Engineering Faculty Research and Publications

We demonstrate the use of heat to count microscopic particles. A thermal particle detector (TPD) was fabricated by combining a 500-nm-thick silicon nitride membrane containing a thin-film resistive temperature detector with a silicone elastomer microchannel. Particles with diameters of 90 and 200 μm created relative temperature changes of 0.11 and −0.44 K, respectively, as they flowed by the sensor. A first-order lumped thermal model was developed to predict the temperature changes. Multiple particles were counted in series to demonstrate the utility of the TPD as a particle counter.

Direct Numerical Simulations Of Non-Premixed Ethylene–Air Flames: Local Flame Extinction Criterion, Vivien R. Lecoustre, Paul G. Grias, Somesh P. Roy, Zhaoyu Luo, Dan C. Haworth, Hong G. Im, Tianfeng F. Lui, Arnaud Trouvé

Mechanical Engineering Faculty Research and Publications

Direct Numerical Simulations (DNS) of ethylene/air diffusion flame extinctions in decaying two-dimensional turbulence were performed. A Damköhler-number-based flame extinction criterion as provided by classical large activation energy asymptotic (AEA) theory is assessed for its validity in predicting flame extinction and compared to one based on Chemical Explosive Mode Analysis (CEMA) of the detailed chemistry. The DNS code solves compressible flow conservation equations using high order finite difference and explicit time integration schemes. The ethylene/air chemistry is simulated with a reduced mechanism that is generated based on the directed relation graph (DRG) based methods along with stiffness removal. The numerical configuration …

A Microsoft Vba Application For Generating Heat Maps, Mark Polczynski, Michael Polczynski

Electrical and Computer Engineering Faculty Research and Publications

A choropleth map is a form of thematic map used to portray the structural characteristics of some particular geographical distribution not apparent in data presented in tabular form. Preparation of a choropleth map starts with the assignment of map features to classes based on the value of a specific feature attribute followed by the association of classes of features with appropriate map colors or symbols. Map features are often geographical regions with naturally or artificially defined boundaries, but choropleth maps can also be prepared by segmenting the area to be mapped into a regular grid of regions. Maps prepared with …

Within-Socket Myoelectric Prediction Of Continuous Ankle Kinematics For Control Of A Powered Transtibial Prosthesis, Samuel Farmer, M. Barbara Silver-Thorn, Philip A. Voglewede, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Objective. Powered robotic prostheses create a need for natural-feeling user interfaces and robust control schemes. Here, we examined the ability of a nonlinear autoregressive model to continuously map the kinematics of a transtibial prosthesis and electromyographic (EMG) activity recorded within socket to the future estimates of the prosthetic ankle angle in three transtibial amputees. Approach. Model performance was examined across subjects during level treadmill ambulation as a function of the size of the EMG sampling window and the temporal 'prediction' interval between the EMG/kinematic input and the model's estimate of future ankle angle to characterize the trade-off between model error, …

A Paper-Based Calorimetric Microfluidics Platform For Bio-Chemical Sensing, Benyamin Davaji, Chung Hoon Lee

Electrical and Computer Engineering Faculty Research and Publications

In this report, a paper-based micro-calorimetric biochemical detection method is presented. Calorimetric detection of biochemical reactions is demonstrated as an extension of current colorimetric and electrochemical detection mechanisms of paper-based biochemical analytical systems. Reaction and/or binding temperature of glucose/glucose oxidase, DNA/hydrogen peroxide, and biotin/streptavidin, are measured by the paper-based micro-calorimeter. Commercially available glucose calibration samples of 0.05, 0.15 and 0.3% wt/vol concentration are used for comparing the device performance with a commercially available glucose meter (electrochemical detection). The calorimetric glucose detection demonstrates a measurement error less than 2%. The calorimetric detection results of DNA concentrations from 0.9 to 7.3 mg/mL …

Application Of Information And Communication Technologies For Historical Research, Michael Polczynski, Mark Polczynski

Electrical and Computer Engineering Faculty Research and Publications

No abstract provided.

Multi-Objective Tradeoffs In The Design Optimization Of A Brushless Permanent-Magnet Machine With Fractional-Slot Concentrated Windings, Peng Zhang, Gennadi Y. Sizov, Muyang Li, Dan M. Ionel, Nabeel Demerdash, Steven J. Stretz, Alan W. Yeadon

Electrical and Computer Engineering Faculty Research and Publications

In this paper, a robust parametric model of a brushless permanent magnet machine with fractional-slot concentrated windings, which was developed for automated design optimization is presented. A computationally efficient finite-element analysis method was employed to estimate the dq-axes inductances, the induced voltage and torque ripple waveforms, and losses of the machine. A method for minimum effort calculation of the torque angle corresponding to the maximum torque per ampere load condition was developed. A differential evolution algorithm was implemented for the global design optimization with two concurrent objectives of minimum losses and minimum material cost. An engineering decision process based on …

Generalized Approach Of Stator Shifting In Interior Permanent-Magnet Machines Equipped With Fractional-Slot Concentrated Windings, Patel B. Reddy, Kum-Kang Huh, Ayman M. El-Refaie

Electrical and Computer Engineering Faculty Research and Publications

Electrical drive systems, which include electrical machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the petroleum dependence of the ground transportation sector. To have significant effect, electric drive technologies must be economical in terms of cost, weight, and size while meeting performance and reliability expectations. Interior permanent magnet machines with fractional-slot concentrated windings have been shown to be good candidates for hybrid traction applications. One of the key challenges is the additional stator magnetomotive force sub- and superharmonic components that lead to higher losses in the rotor as well as saturation effects. …

Entrepreneurship In Capstone Design: Has The Pendulum Swung Too Far?, Jay R. Goldberg

Biomedical Engineering Faculty Research and Publications

The author supports entrepreneurial education for all interested students, but not at the expense of design education. He thinks we should develop business literacy among all of our students to prepare them for work in start-ups and established medical device companies, and provide opportunities for interested students to add entrepreneurial literacy to better prepare them to create new companies, either upon graduation or later in their careers. Capstone design courses should focus on helping students develop solid design skills and providing opportunities to apply the analytical tools learned in previous courses. Students should be encouraged, not required, to consider commercializing …

Reduced Diaphyseal Strength Associated With High Intracortical Vascular Porosity Within Long Bones Of Children With Osteogenesis Imperfecta, Carolyne Albert, John Jameson, Peter Smith, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Osteogenesis imperfecta is a genetic disorder resulting in bone fragility. The mechanisms behind this fragility are not well understood. In addition to characteristic bone mass deficiencies, research suggests that bone material properties are compromised in individuals with this disorder. However, little data exists regarding bone properties beyond the microstructural scale in individuals with this disorder.

Specimens were obtained from long bone diaphyses of nine children with osteogenesis imperfecta during routine osteotomy procedures. Small rectangular beams, oriented longitudinally and transversely to the diaphyseal axis, were machined from these specimens and elastic modulus, yield strength, and maximum strength were measured in three-point …

Comparative Assessment Of Diverse Strategies For Malaria Vector Population Control Based On Measured Rates At Which Mosquitoes Utilize Targeted Resource Subsets, Gerry F. Killeen, Samson Sifael Kiware, Aklilu Seyoum, John E. Gimnig, George Corliss, Jennifer Stevenson, Christopher J. Drakeley, Nakul Chitnis

Electrical and Computer Engineering Faculty Research and Publications

Background

Eliminating malaria requires vector control interventions that dramatically reduce adult mosquito population densities and survival rates. Indoor applications of insecticidal nets and sprays are effective against an important minority of mosquito species that rely heavily upon human blood and habitations for survival. However, complementary approaches are needed to tackle a broader diversity of less human-specialized vectors by killing them at other resource targets.

Methods

Impacts of strategies that target insecticides to humans or animals can be rationalized in terms of biological coverage of blood resources, quantified as proportional coverage of all blood resources mosquito vectors utilize. Here, this concept …

Therapeutic Potential Of Haptic Theradrive: An Affordable Robot/Computer System For Motivating Stroke Rehabilitation, Andrew Theriualt, Mark L. Nagurka, Michelle J. Johnson

Mechanical Engineering Faculty Research and Publications

There is a need for increased opportunities for effective neurorehabilitation services for stroke survivors outside the hospital environment. Efforts to develop low-cost robot/computer therapy solutions able to be deployed in home and community rehabilitation settings have been growing. Our long-term goal is to develop a very low-cost system for stroke rehabilitation that can use commercial gaming technology and support rehabilitation with stroke survivors at all functioning levels. This paper reports the results of experiments comparing the old and new TheraDrive systems in terms of ability to assist/resist subjects and the root-mean-square (RMS) trajectory tracking error. Data demonstrate that the new …

Non-Common Path Aberration Correction In An Adaptive Optics Scanning Ophthalmoscope, Yusufu N. Sulai, Alfredo Dubra

Biomedical Engineering Faculty Research and Publications

The correction of non-common path aberrations (NCPAs) between the imaging and wavefront sensing channel in a confocal scanning adaptive optics ophthalmoscope is demonstrated. NCPA correction is achieved by maximizing an image sharpness metric while the confocal detection aperture is temporarily removed, effectively minimizing the monochromatic aberrations in the illumination path of the imaging channel. Comparison of NCPA estimated using zonal and modal orthogonal wavefront corrector bases provided wavefronts that differ by ~λ/20 in root-mean-squared (~λ/30 standard deviation). Sequential insertion of a cylindrical lens in the illumination and light collection paths of the imaging channel was used to compare image resolution …

The Reliability Of Parafoveal Cone Density Measurements, Benjamin S. Liu, Sergey Tarima, Alexis D. Visotcky, Alex Pechauer, Robert F. Cooper, Leah Landsem, Melissa A. Wilk, Pooja Godara, Vikram Makhijani, Yusufu N. Sulai, Najia Syed, Galen Yasumura, Anupam K. Garg, Mark E. Pennesi, Brandon J. Lujan, Alfredo Dubra, Jacque L. Duncan, Joseph Carroll

Biomedical Engineering Faculty Research and Publications

Background Adaptive optics scanning light ophthalmoscopy (AOSLO) enables direct visualisation of the cone mosaic, with metrics such as cone density and cell spacing used to assess the integrity or health of the mosaic. Here we examined the interobserver and inter-instrument reliability of cone density measurements.

Methods For the interobserver reliability study, 30 subjects with no vision-limiting pathology were imaged. Three image sequences were acquired at a single parafoveal location and aligned to ensure that the three images were from the same retinal location. Ten observers used a semiautomated algorithm to identify the cones in each image, and this was repeated …

Upper Extremity Biomechanics Of Children With Spinal Cord Injury During Wheelchair Mobility, Alyssa J. Schnorenberg, Brooke A. Slavens, Adam Graf, Joseph J. Krzak, Lawrence C. Vogel, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

While much work is being done evaluating the upper extremity joint dynamics of adult manual wheelchair propulsion, limited work has examined the pediatric population of manual wheelchair users. Our group used a custom pediatric biomechanical model to characterize the upper extremity joint dynamics of 12 children and adolescents with spinal cord injury (SCI) during wheelchair propulsion. Results show that loading appears to agree with that of adult manual wheelchair users, with the highest loading primarily seen at the glenohumeral joint. This is concerning due to the increased time of wheelchair use in the pediatric population and the impact of this …

Deterministic And Stochastic Resilience Analysis Of Minimum-Time-Controlled Discrete-Time Systems, Jennifer L. Bonniwell, Susan C. Schneider Phd, Edwin E. Yaz

Electrical and Computer Engineering Faculty Research and Publications

The resilience of discrete-time systems subject to minimum-time control is analysed for both deterministic and stochastic control gain perturbations. Lyapunov analysis is used to determine a tight upper bound on the control gain perturbations to maintain asymptotic stability.

Panel I: Connecting 2nd Law Analysis With Economics, Ecology And Energy Policy, Richard Gaggioli, Mauro Reini

Mechanical Engineering Faculty Research and Publications

The present paper is a review of several papers from the Proceedings of the Joint European Thermodynamics Conference, held in Brescia, Italy, 1–5 July 2013, namely papers introduced by their authors at Panel I of the conference. Panel I was devoted to applications of the Second Law of Thermodynamics to social issues—economics, ecology, sustainability, and energy policy. The concept called Available Energy which goes back to mid-nineteenth century work of Kelvin, Rankine, Maxwell and Gibbs, is relevant to all of the papers. Various names have been applied to the concept when interactions between the system of interest and an environment …

Stochastic Analysis Of Cascading-Failure Dynamics In Power Grids, Mahshid Rahnamay-Naeini, Zhuoyao Wang, Nasir Ghani, Andrea Mammoli, Majeed M. Hayat

Electrical and Computer Engineering Faculty Research and Publications

A scalable and analytically tractable probabilistic model for the cascading failure dynamics in power grids is constructed while retaining key physical attributes and operating characteristics of the power grid. The approach is based upon extracting a reduced abstraction of large-scale power grids using a small number of aggregate state variables while modeling the system dynamics using a continuous-time Markov chain. The aggregate state variables represent critical power-grid attributes, which have been shown, from prior simulation-based and historical-data-based analysis, to strongly influence the cascading behavior. The transition rates among states are formulated in terms of certain parameters that capture grid's operating …

Effect Of Lowest Instrumented Vertebra On Trunk Mobility In Patients With Adolescent Idiopathic Scoliosis Undergoing A Posterior Spinal Fusion, Ubong I. Udoekwere, Joseph Krzak, Adam Graf, Sahar Hassani, Sergey Tarima, Mary Riordan, Peter F. Sturm, Kim W. Hammerberg, Purnendu Gupta, Alireza K. Anissipour, Gerald F. Harris

Biomedical Engineering Faculty Research and Publications

Study Design

Prospective.

Objectives

The goal of this study was to evaluate the effect of posterior spinal fusion surgery terminating at different lowest instrumented vertebrae (LIV) on trunk mobility in individuals with adolescent idiopathic scoliosis (AIS).

Summary of Background Data

Posterior spinal fusion with instrumentation is the standard surgical technique employed in AIS for correcting spine deformities with Cobb angles exceeding 50°. Surgical correction of curve deformity reduces trunk mobility and range of motion. However, conflicting findings from previous studies investigating the impact of different LIV levels on the reduction in trunk mobility after surgery have been reported.

Methods

The …

Relationship Between Foveal Cone Specialization And Pit Morphology In Albinism, Melissa A. Wilk, John T. Mcallister, Robert F. Cooper, Adam M. Dubis, Teresa N. Patitucci, Phyllis Summerfelt, Jennifer L. Anderson, Deborah M. Costakos, Thomas B. Connor Jr., William J. Wirostko, Pei-Wen Chiang, Alfredo Dubra, Christine A. Curcio, Murray H. Briliant, C. Gail Summers, Joseph Carroll, Jennifer L. Anderson

Biomedical Engineering Faculty Research and Publications

Purpose. Albinism is associated with disrupted foveal development, though intersubject variability is becoming appreciated. We sought to quantify this variability, and examine the relationship between foveal cone specialization and pit morphology in patients with a clinical diagnosis of albinism.

Methods. We recruited 32 subjects with a clinical diagnosis of albinism. DNA was obtained from 25 subjects, and known albinism genes were analyzed for mutations. Relative inner and outer segment (IS and OS) lengthening (fovea-to-perifovea ratio) was determined from manually segmented spectral domain-optical coherence tomography (SD-OCT) B-scans. Foveal pit morphology was quantified for eight subjects from macular SD-OCT volumes. Ten subjects …

Microscopic Inner Retinal Hyper-Reflective Phenotypes In Retinal And Neurologic Disease, Drew Scoles, Brian P. Higgins, Robert F. Cooper, Adam M. Dubis, Phyllis Summerfelt, David V. Weinberg, Judy E. Kim, Kimberly E. Stepien, Joseph Carroll, Alfredo Dubra

Biomedical Engineering Faculty Research and Publications

Purpose.

We surveyed inner retinal microscopic features in retinal and neurologic disease using a reflectance confocal adaptive optics scanning light ophthalmoscope (AOSLO).

Methods.

Inner retinal images from 101 subjects affected by one of 38 retinal or neurologic conditions and 11 subjects with no known eye disease were examined for the presence of hyper-reflective features other than vasculature, retinal nerve fiber layer, and foveal pit reflex. The hyper-reflective features in the AOSLO images were grouped based on size, location, and subjective texture. Clinical imaging, including optical coherence tomography (OCT), scanning laser ophthalmoscopy, and fundus photography was analyzed for comparison.

Results.

Seven …

Seismic Response Of A Tall Building To Recorded And Simulated Ground Motions, Nenad Bijelic, Ting Lin, Gregory Deierlein

Civil and Environmental Engineering Faculty Research and Publications

Seismological modeling technologies are advancing to the stage of enabling fundamental simulation of earthquake fault ruptures, which offer new opportunities to simulate extreme ground motions for collapse safety assessment and earthquake scenarios for community resilience studies. With the goal toward establishing the reliability of simulated ground motions for performance-based engineering, this paper examines the response of a 20-story concrete moment frame building analyzed by nonlinear dynamic analysis under corresponding sets of recorded and simulated ground motions. The simulated ground motions were obtained through a larger validation study via the Southern California Earthquake Center (SCEC) Broadband Platform (BBP) that simulates magnitude …

Measuring Tumor Cycling Hypoxia And Angiogenesis Using A Side-Firing Fiber Optic Probe, Bing Yu, Amy Shah, Bingqing Wang, Narasimhan Rajaram, Quanli Wang, Nirmala Ramanujam, Gregory M. Palmer, Mark W. Dewhirst

Biomedical Engineering Faculty Research and Publications

Hypoxia and angiogenesis can significantly influence the efficacy of cancer therapy and the behavior of surviving tumor cells. There is a growing demand for technologies to measure tumor hypoxia and angiogenesis temporally in vivo to enable advances in drug development and optimization. This paper reports the use of frequency-domain photon migration with a side-firing probe to quantify tumor oxygenation and hemoglobin concentrations in nude rats bearing human head/neck tumors administered with carbogen gas, cycling hypoxic gas or just room air. Significant increase (with carbogen gas breathing) or decrease (with hypoxic gas breathing) in tumor oxygenation was observed. The trend in …

Detailed Computational Modeling Of Laminar And Turbulent Sooting Flames, Adhiraj Dasgupta, Somesh Roy, Daniel C. Haworth

Mechanical Engineering Faculty Research and Publications

This study reports development and validation of two parallel flame solvers with soot models based on the open-source computation fluid dynamics (CFD) toolbox code OpenF0AM. First, a laminar flame solver is developed and validated against experimental data. A semi-empirical two-equation soot model and a detailed soot model using a method of moments with interpolative closure (MOMIC) are implemented in the laminar flame solver. An optically thin radiation model including gray soot radiation is also implemented. Preliminary results using these models show good agreement with experimental data for the laminar axisymmetric diffusion flame studied. Second, a turbulent flame solver is developed …

Terahertz Photoacoustic Spectroscopy Using An Mems Cantilever Sensor, Nathan E. Giauvitz, Ronald A. Coutu Jr., Ivan R. Medvedev, Douglas T. Petkie

Electrical and Computer Engineering Faculty Research and Publications

In this paper, a microelectromechanical systems cantilever sensor was designed, modeled, and fabricated to measure the photoacoustic (PA) response of gases under very low vacuum conditions. The micromachined devices were fabricated using silicon-on-insulator wafers and then tested in a custom-built, miniature, vacuum chamber during this first-ever demonstration. Terahertz radiation was amplitude modulated to excite the gas under test and perform PA molecular spectroscopy. Experimental data show a predominantly linear response that directly correlates measured cantilever deflection to PA signals. Excellent low pressure (i.e., 2-40 mTorr) methyl cyanide PA spectral data were collected resulting in a system sensitivity of 1.97 × …

Looking For Your Next Disruptive Technology? Try Student Competitions, Jay R. Goldberg, Phil Weilerstein

Biomedical Engineering Faculty Research and Publications

No abstract provided.