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Articles 1 - 2 of 2
Full-Text Articles in Engineering
Technobiology Paradigm In Nanomedicine: Treating Cancer With Magnetoelectric Nanoparticles, Emmanuel Stimphil
Technobiology Paradigm In Nanomedicine: Treating Cancer With Magnetoelectric Nanoparticles, Emmanuel Stimphil
FIU Electronic Theses and Dissertations
Today, cancer is the world’s deadliest disease. Despite significant progress to find a cure, especially over the last decade, with immunotherapy rapidly becoming the state of the art, major open questions remain. Each successful therapy is not only limited to a few cancers but also has relatively low specificity to target cancer cells; although cancer cells can indeed be eradicated, many normal cells are sacrificed as collateral damage. To fill this gap, we have developed a class of multiferroic nanostructures known as magnetoelectric nanoparticles (MENs) that can be used to enable externally controlled high-specificity targeted delivery and release of therapeutic …
The Effect Of Hyperthermia On Doxorubicin Therapy And Nanoparticle Penetration In Multicellular Ovarian Cancer Spheroids, Abhignyan Nagesetti
The Effect Of Hyperthermia On Doxorubicin Therapy And Nanoparticle Penetration In Multicellular Ovarian Cancer Spheroids, Abhignyan Nagesetti
FIU Electronic Theses and Dissertations
The efficient treatment of cancer with chemotherapy is challenged by the limited penetration of drugs into the tumor. Nanoparticles (10 – 100 nanometers) have emerged as a logical choice to specifically deliver chemotherapeutics to tumors, however, their transport into the tumor is also impeded owing to their bigger size compared to free drug moieties. Currently, monolayer cell cultures, as models for drug testing, cannot recapitulate the structural and functional complexity of in-vivo tumors. Furthermore, strategies to improve drug distribution in tumor tissues are also required. In this study, we hypothesized that hyperthermia (43°C) will improve the distribution of silica nanoparticles …