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Full-Text Articles in Engineering
Evaluation Of A Microfluidic Mixer Utilizing Staggered Herringbone Channels: A Computational Fluid Dynamics Approach, Brian Hama
ETD Archive
Microfluidic platforms offer a variety of advantages including improved heat transfer, low working volumes, ease of scale-up, and strong user control on parameters. However, flow within microfluidic channels occurs at low Reynolds numbers, which makes mixing difficult to accomplish. Adding V-shaped ridges to channel walls, a pattern called the staggered herringbone design (SHB), might alleviate this problem by introducing transverse flow patterns that enable enhanced mixing. However, certain factors affecting the SHB mixer’s performance remain largely unexplored.
In this work, a microfluidic mixer utilizing the SHB geometry was developed and characterized using computational fluid dynamics based simulations and complimentary experiments. …
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
A Cfd Model Of Mixing In A Microfludic Device For Space Medicine Technology, Terri Lynn Mckay
ETD Archive
The DNA Medicine Institute (DMI) is currently developing a device to be used for blood analysis to satisfy the unique requirements of space medicine applications. A key component of that device is the micromixer, which will ensure mixing and dilution of reagents utilized for detection assays. As part of the device design process, the micromixer was modeled, and the mixing characteristics were analyzed and compared to experimental data. The experimental data was based on a top-view of the system and, lacking data throughout the fluid domain, could not provide the insight into the mixing process that modeling could readily provide. …
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
ETD Archive
Microfluidic platforms for magnetic cell separation were developed and investigated for isolation of magnetic particles and magnetically tagged cells from a fluidic sample. Two types of magnetic separation platforms were considered: an Isodynamic Open Gradient Magnetic Sorter (OGMS) and a multistage bio-ferrograph. Miniaturized magnets were designed using magnetostatic simulation software, microfluidic channels were fabricated using microfabrication technology and magnetic separation was investigated using video microscopy and digital image processing. The isodynamic OGMS consisted of an external magnetic circuit and a microfabricated channel (biochip) with embedded magnetic elements. The biochip is placed inside the magnetic field of the external circuit to …