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Articular Cartilage Mechanical And Biochemical Property Relations Before And After In Vitro Growth, Timothy Ficklin, Gregory Thomas, James C. Barthel, Anna Asanbaeva, Eugene J. Thonar, Koichi Masuda, Albert C. Chen, Robert L. Sah, Andrew Davol, Stephen M. Klisch
Articular Cartilage Mechanical And Biochemical Property Relations Before And After In Vitro Growth, Timothy Ficklin, Gregory Thomas, James C. Barthel, Anna Asanbaeva, Eugene J. Thonar, Koichi Masuda, Albert C. Chen, Robert L. Sah, Andrew Davol, Stephen M. Klisch
Mechanical Engineering
The aim of this study was to design in vitro growth protocols that can comprehensively quantify articular cartilage structure–function relations via measurement of mechanical and biochemical properties. Newborn bovine patellofemoral groove articular cartilage explants were tested sequentially in confined compression (CC), unconfined compression (UCC), and torsional shear before (D0, i.e. day zero) and after (D14, i.e. day 14) unstimulated in vitro growth. The contents of collagen (COL), collagen-specific pyridinoline (PYR) crosslinks, glycosaminoglycan, and DNA significantly decreased during in vitro growth; consequently, a wide range of biochemical properties existed for investigating structure–function relations when pooling the D0 and D14 groups. All …
The Biomechanical Aspects Of Pedestrian Protection, Krishnakanth Aekbote, Peter Schuster, Sunny Kankanala, Srini Sundararajan, Stephen W. Rouhana
The Biomechanical Aspects Of Pedestrian Protection, Krishnakanth Aekbote, Peter Schuster, Sunny Kankanala, Srini Sundararajan, Stephen W. Rouhana
Mechanical Engineering
In this paper a biomechanical basis for pedestrian protection is presented based on reviews of epidemiological and biomechanical studies conducted over the last three decades. Epidemiological studies reveal the nature and cause of pedestrian crashes and injuries sustained in the field. The various factors that influence pedestrian crashes and fatalities such as pedestrian demographics, time and location of crash, type of vehicles involved and their design characteristics, impact speeds, and nature and severity of injuries sustained are covered in the epidemiology section. The biomechanical studies identify the injury mechanisms and the biomechanical tolerances. Several biomechanical studies that attempt to identify …
A Theory Of Volumetric Growth For Compressible Elastic Biological Materials, Stephen M. Klisch, Timothy J. Van Dyke, Anne Hoger
A Theory Of Volumetric Growth For Compressible Elastic Biological Materials, Stephen M. Klisch, Timothy J. Van Dyke, Anne Hoger
Mechanical Engineering
A general theory of volumetric growth for compressible elastic materials is presented. The authors derive a complete set of governing equations in the present configuration for an elastic material undergoing a continuous growth process. In particular, they obtain two constitutive restrictions from a work-energy principle. First, the authors show that a growing elastic material behaves as a Green-elastic material. Second, they obtain an expression that relates the stress power due to growth to the rate of energy change due to growth. Then, the governing equations for a small increment of growth are derived from the more general theory. The equations …