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Integrating Qplm And Biomedical Test Data With An Anisotropic Fiber Distribution Model And Predictions Of Tgf-Β1 And Igf-1 Regulation Of Articular Cartilage Fiber Modulus, Michael E. Stender, Christopher B. Raub, Kevin A. Yamauchi, Reza Shirazi, Pasquale Vena, Robert L. Sah, Scott J. Hazelwood, Stephen M. Klisch
Integrating Qplm And Biomedical Test Data With An Anisotropic Fiber Distribution Model And Predictions Of Tgf-Β1 And Igf-1 Regulation Of Articular Cartilage Fiber Modulus, Michael E. Stender, Christopher B. Raub, Kevin A. Yamauchi, Reza Shirazi, Pasquale Vena, Robert L. Sah, Scott J. Hazelwood, Stephen M. Klisch
Mechanical Engineering
A continuum mixture model with distinct collagen (COL) and glycosaminoglycan elastic constituents was developed for the solid matrix of immature bovine articular cartilage. A continuous COL fiber volume fraction distribution function and a true COL fiber elastic modulus ( Ef) were used. Quantitative polarized light microscopy (qPLM) methods were developed to account for the relatively high cell density of immature articular cartilage and used with a novel algorithm that constructs a 3D distribution function from 2D qPLM data. For specimens untreated and cultured in vitro, most model parameters were specified from qPLM analysis and biochemical assay results; consequently, Ef was …