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Articles 1 - 4 of 4
Full-Text Articles in Engineering
Transport Barriers Influence The Activation Of Anti-Tumor Immunity: A Systems Biology Analysis, Mohammad R. Nikmaneshi, James W. Baish, Hengbo Zhou, Lance L. Munn
Transport Barriers Influence The Activation Of Anti-Tumor Immunity: A Systems Biology Analysis, Mohammad R. Nikmaneshi, James W. Baish, Hengbo Zhou, Lance L. Munn
Faculty Journal Articles
Effective anti-cancer immune responses require activation of one or more naïve T cells. If the correct naïve T cell encounters its cognate antigen presented by an antigen presenting cell, then the T cell can activate and proliferate. Here, mathematical modeling is used to explore the possibility that immune activation in lymph nodes is a rate-limiting step in anti-cancer immunity and can affect response rates to immune checkpoint therapy. The model provides a mechanistic framework for optimizing cancer immunotherapy and developing testable solutions to unleash anti-tumor immune responses for more patients with cancer. The results show that antigen production rate and …
An Lp-Based Characterization Of Solvable Qap Instances With Chess-Board And Graded Structures, Lucas Waddell, Jerry Phillips, Tianzhu Liu, Swarup Dhar
An Lp-Based Characterization Of Solvable Qap Instances With Chess-Board And Graded Structures, Lucas Waddell, Jerry Phillips, Tianzhu Liu, Swarup Dhar
Faculty Journal Articles
The quadratic assignment problem (QAP) is perhaps the most widely studied nonlinear combinatorial optimization problem. It has many applications in various fields, yet has proven to be extremely difficult to solve. This difficulty has motivated researchers to identify special objective function structures that permit an optimal solution to be found efficiently. Previous work has shown that certain such structures can be explained in terms of a mixed 0-1 linear reformulation of the QAP known as the level-1 reformulation-linearization-technique (RLT) form. Specifically, the objective function structures were shown to ensure that a binary optimal extreme point solution exists to the continuous …
Integration Of Public Policy Into Civil Engineering Undergraduate Curricula: Review Of Civil Engineering Body Of Knowledge And Course Application, Michelle R. Oswald Beiler
Integration Of Public Policy Into Civil Engineering Undergraduate Curricula: Review Of Civil Engineering Body Of Knowledge And Course Application, Michelle R. Oswald Beiler
Faculty Conference Papers and Presentations
The field of civil and environmental engineering directly ties with serving the needs of the public through infrastructure development and improvements in sustainable environments. Integrating this reciprocal connection between public policy and civil engineering into undergraduate civil engineering education is critical for the preparation of the next generation of engineers. This project, first, reviews the guidance of public policy in civil engineering programs, such as ASCE’s Civil Engineering Body of Knowledge. Then, a pedagogical application is presented that focuses on the integration of public policy concepts, methods, assessment tools and techniques in a required, upper level course in civil and …
Piv Measurements Of Open-Channel Turbulent Flow Under Unconstrained Conditions, James K. Arthur
Piv Measurements Of Open-Channel Turbulent Flow Under Unconstrained Conditions, James K. Arthur
Faculty Journal Articles
Many open-channel turbulent flow studies have been focused on highly constrained conditions. Thus, it is rather conventional to note such flows as being fully developed, fully turbulent, and unaffected by sidewalls and free surface disturbances. However, many real-life flow phenomena in natural water bodies and artificially installed drain channels are not as ideal. This work is aimed at studying some of these unconstrained conditions. This is achieved by using particle image velocimetry measurements of a developing turbulent open-channel flow over a smooth wall. The tested flow effects are low values of the Reynolds number based on the momentum thickness Re …