Engineering Commons^™

Machine Learning Based Applications For Data Visualization, Modeling, Control, And Optimization For Chemical And Biological Systems, Yan Ma

LSU Doctoral Dissertations

This dissertation report covers Yan Ma’s Ph.D. research with applicational studies of machine learning in manufacturing and biological systems. The research work mainly focuses on reaction modeling, optimization, and control using a deep learning-based approaches, and the work mainly concentrates on deep reinforcement learning (DRL). Yan Ma’s research also involves with data mining with bioinformatics. Large-scale data obtained in RNA-seq is analyzed using non-linear dimensionality reduction with Principal Component Analysis (PCA), t-Distributed Stochastic Neighbor Embedding (t-SNE), and Uniform Manifold Approximation and Projection (UMAP), followed by clustering analysis using k-Means and Hierarchical Density-Based Spatial Clustering with Noise (HDBSCAN). This report focuses …

Experimental And Numerical Study Of Polymorphism In Crystallization Processes, Mengxing Lin

Electronic Thesis and Dissertation Repository

Polymorphism, which is exhibited in more than half of the active pharmaceutical ingredients, has a direct impact on the stability, bioavailability and processability of the product. Despite extensive studies on polymorphism in the field of crystal engineering, the control of polymorphism is still one of the most challenging tasks in pharmaceutical manufacturing.

The aim of this work is to crystallize the desired polymorph with the help of process modeling and process analytical technologies. First, we investigated the crystallization properties of imatinib mesylate, including polymorphism characterization, solubility measurement, polymorphic transformation and kinetic parameter estimation, as they are the fundamental information for …

Thermal Control Development Of A Proton Exchange Membrane Fuel Cell System, Ola Mohammed Taha Al-Shalash

Mechanical Engineering Theses

A fuel cell is an electrochemical energy conversion device that uses fuel to generate electricity. It basically converts the chemical energy of reactants directly into electricity without combustion. In a Proton Exchange Membrane Fuel Cell (PEMFC), the reactants, hydrogen and oxygen, are fed into the two electrodes, anode and cathode, respectively. A reaction takes place at each electrode and produces electricity, as well as water, and heat as the by-products. In order to maximize performance of a fuel cell, many factors can be considered for tuning and control. Temperature management is one of these factors.

A thermal-fluid model of a …

Improved Fermentation Design And Screening Devices For Biobutanol Production, Garret Christopher Munch

Electronic Thesis and Dissertation Repository

A worldwide increase in demand for renewable fuels has revived interest in fermentatively produced butanol. However, butanol fermentation suffers from low product yields and productivity. The work presented in this thesis addresses part of these research and development needs at three levels: innovative fermentation process design; genetic manipulation for strain enhancement; and the development of a new tool for anaerobic process characterization and optimization.

Product yield could be increased through traditional fermentation engineering. Co-fermentation of butyric acid with glycerol increased the butanol yield from 0.45 mol/mol (mols C in butanol / mol C in substrates) to 0.51 mol/mol. In building …

Techno-Economic Analysis On The Recovery & Valorization Of Lithium From Recycled Battery Waste Materials By Hydrometallurgical Methods., Preston N. Nicely, Noah Dunlap, Joseph Swann, John Hill

Chancellor’s Honors Program Projects

No abstract provided.

Labview Improvements And Equipment Redesign Of Unit Operations Distillation Column, Madalyn S Wead

Electronic Theses and Dissertations

Unit Operations labs are important tools to provide hands-on learning with various chemical processes. The distillation lab experiment allows students to connect equations and definitions from textbooks to the physical processes of distillation as they occur. LabVIEW was the software development tool used to create a program to control the distillation column from startup to shutdown. Improvements were made to both the distillation process equipment and the LabVIEW code to create a more interactive lab experience, enhance students’ conceptual understanding of distillation, and prepare students for their future career as chemical engineers.

Equipment addressed included non-linear valves, malfunctioning temperature and …

Techno-Economic Analysis Of Acetaldehyde Production Via Partial Oxidative Dehydrogenation Of Ethanol, Sudarat Sompong

Chulalongkorn University Theses and Dissertations (Chula ETD)

Due to the increased attention regarding the battery electric vehicles, the demand for ethanol as a biofuel may be reduced in the future. Therefore, ethanol transformation towards acetaldehyde is conducted in this work, primarily because of the higher selling price and several advantages of acetaldehyde. Regarding the acetaldehyde preparation, acetaldehyde is produced by partial oxidative dehydrogenation of ethanol. According to the economic analysis results, at the same price of acetaldehyde, an annual production capacity of 120,000 tons is the most profitable production size. In addition, the potential process of producing acetaldehyde from ethanol is acetaldehyde production process at 200°C since …

Modeling Of Rotary Packed Beds For Reactive And Non-Reactive Systems, Chinyere Evangeline Ezeobinwune

Graduate Theses, Dissertations, and Problem Reports

Rotary packed beds (RPBs) are used in a wide range of reactive and non-reactive applications. In this research, a 2-d, first-principles, dynamic model of a non-reactive RPB that is used for heat exchange between the outgoing flue gas from a power plant and the incoming air to the boiler/pulverizer of the power plant is developed. A 2-d, first-principles model of a reactive RPB is developed where a functionalized metal-organic framework (MOF) is used for CO₂ capture.

For the non-reactive system, a Ljungstrom-type air preheater (APH) is considered. Existing models for these rotating heat exchangers are typically 1-d. There are …