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Full-Text Articles in Engineering
Enhancing The Intracellular Availability Of Protein Cargoes In Polymer-Mediated Delivery, Christopher R. Hango
Enhancing The Intracellular Availability Of Protein Cargoes In Polymer-Mediated Delivery, Christopher R. Hango
Doctoral Dissertations
Protein drugs, including antibodies, are rapidly emerging as the top-selling pharmaceuticals worldwide owing to their unparalleled specificity and biocompatibility. However, none of the currently-approved protein therapeutics act intracellularly, despite the vast majority of potential drug targets residing within the cell. This is due mainly to the paramount challenge of transporting hydrophilic macromolecular cargoes across the plasma membrane. As such, effective protein carriers are essential for the advancement of modern medicine. Despite significant advances, many challenges still plague protein delivery. Following membrane transduction, delivery vectors must preserve the structure and activity of their cargoes while transporting them to the correct subcellular …
Source Data For "End Exclusion Zones In Strongly Stretched, Molten Polymer Brushes Of Arbitrary Shape", Michael S. Dimitriyev, Gregory M. Grason
Source Data For "End Exclusion Zones In Strongly Stretched, Molten Polymer Brushes Of Arbitrary Shape", Michael S. Dimitriyev, Gregory M. Grason
Data and Datasets
Supplementary code for solving the constraint equations that describe curved polymer brushes. Also contains software for analyzing the resulting solutions.