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Itraconazole Nanocomposites Prepared Via Rotary Evaporator Drying Of Nanomilled Suspensions, Alexander Santos Coelho
Itraconazole Nanocomposites Prepared Via Rotary Evaporator Drying Of Nanomilled Suspensions, Alexander Santos Coelho
Theses
The aim of this study is to explore the feasibility of rotary evaporation for drying wetmilled drug suspensions as a novel approach to produce drug nanocomposites that exhibit fast redispersion and immediate drug release. To this end, the physical stability of the nanomilled itraconazole (drug) suspensions, a.k.a., nanosuspensions, during the milling and storage; the drying of the itraconazole nanosuspensions via the rotary evaporator; and the type/loading of various polymers/surfactants (dispersants) on aqueous redispersion and drug release from the nanocomposites were examined. Our results suggest that smaller drug particle size, owing to nanomilling, and smaller nanocomposite particle size, owing to optimized …
Preparation And Characterization Of Reactive Composites Combining Boron With Mixed Oxides, Purvam Mehulkumar Gandhi
Preparation And Characterization Of Reactive Composites Combining Boron With Mixed Oxides, Purvam Mehulkumar Gandhi
Theses
Thirteen liquids have been explored as Process Control Agents (PCAs) for high-energy mechanical milling of two metal oxide powders, CuO and Bi2O3, with the practical purpose to reduce the sizes of powder particles and refine their crystal structure. Multiple liquid properties have been considered to analyze their effect on evolution of both particle and crystallite sizes during milling for each oxide. Experimental data were analyzed using the δ-AICc (Akaike Information criterion) correlation function applied to linear relations between liquid properties and powder characteristics. Multiple linear correlation models were ranked based on the highest log-likelihood and the …
The Use Of Electrical Resistance Tomography To Determine The Minimum Agitation Speed For Solids Suspension In Stirred Tank Reactors, Baran Teoman
Theses
Njs, the minimum agitation speed needed to just suspend all the solid particles in a solid-liquid mixture stirred in an agitated vessel, is a critical parameter to properly operate industrial tanks in a large number of industrial operations. As a result, a significant literature on Njs is available. The oldest and the most common method to measure Njs experimentally is that of Zwietering’s (Chem. Eng. Sci., 1958, 8, 244-253), where Njs can be visually obtained by determining when the solids stay at the bottom of the tank for no more than 1-2 seconds before being swept away. Although this has …