Engineering Commons^™

Cytoskeletal Strains In Modeled Optohydrodynamically Stressed Healthy And Diseased Biological Cells, Sean S. Kohles, Yu Liang, Asit K. Saha

Mechanical and Materials Engineering Faculty Publications and Presentations

Controlled external chemomechanical stimuli have been shown to influence cellular and tissue regeneration/degeneration, especially with regards to distinct disease sequelae or health maintenance. Recently, a unique three-dimensional stress state was mathematically derived to describe the experimental stresses applied to isolated living cells suspended in an optohydrodynamic trap (optical tweezers combined with microfluidics). These formulae were previously developed in two and three dimensions from the fundamental equations describing creeping flows past a suspended sphere. The objective of the current study is to determine the full-field cellular strain response due to the applied three-dimensional stress environment through a multiphysics computational simulation. In …