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Hybrid Photomultiplier Tube And Photodiode Parallel Detection Array For Wideband Optical Spectroscopy Of The Breast Guided By Magnetic Resonance Imaging, Fadi El-Ghussein, Michael A. Mastanduno, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen
Hybrid Photomultiplier Tube And Photodiode Parallel Detection Array For Wideband Optical Spectroscopy Of The Breast Guided By Magnetic Resonance Imaging, Fadi El-Ghussein, Michael A. Mastanduno, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen
Dartmouth Scholarship
A new optical parallel detection system of hybrid frequency and continuous-wave domains was developed to improve the data quality and accuracy in recovery of all breast optical properties. This new system was deployed in a previously existing system for magnetic resonance imaging (MRI)-guided spectroscopy, and allows incorporation of additional near-infrared wavelengths beyond 850 nm, with interlaced channels of photomultiplier tubes (PMTs) and silicon photodiodes (PDs). The acquisition time for obtaining frequency-domain data at six wavelengths (660, 735, 785, 808, 826, and 849 nm) and continuous-wave data at three wavelengths (903, 912, and 948 nm) is 12 min. The dynamic ranges …
Comparison Of Magnetic Resonance Imaging-Compatible Optical Detectors For In-Magnet Tissue Spectroscopy: Photodiodes Versus Silicon Photomultipliers, Fadi El-Ghussein, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen, Brian W. Pogue
Comparison Of Magnetic Resonance Imaging-Compatible Optical Detectors For In-Magnet Tissue Spectroscopy: Photodiodes Versus Silicon Photomultipliers, Fadi El-Ghussein, Shudong Jiang, Brian W. Pogue, Keith D. Paulsen, Brian W. Pogue
Dartmouth Scholarship
Tissue spectroscopy inside the magnetic resonance imaging (MRI) system adds a significant value by measuring fast vascular hemoglobin responses or completing spectroscopic identification of diagnostically relevant molecules. Advances in this type of spectroscopy instrumentation have largely focused on fiber coupling into and out of the MRI; however, nonmagnetic detectors can now be placed inside the scanner with signal amplification performed remotely to the high field environment for optimized light detection. In this study, the two possible detector options, such as silicon photodiodes (PD) and silicon photomultipliers (SiPM), were systematically examined for dynamic range and wavelength performance. Results show that PDs …
Spatial Frequency Analysis Of Anisotropic Drug Transport In Tumor Samples, Stewart Russell, Kimberley S. Samkoe, Jason R. Gunn, P Jack Hoopes, Thienan A. Nguyen, Milo J. Russell, Robert R. Alfano, Brian W. Pogue
Spatial Frequency Analysis Of Anisotropic Drug Transport In Tumor Samples, Stewart Russell, Kimberley S. Samkoe, Jason R. Gunn, P Jack Hoopes, Thienan A. Nguyen, Milo J. Russell, Robert R. Alfano, Brian W. Pogue
Dartmouth Scholarship
Directional Fourier spatial frequency analysis was used on standard histological sections to identify salient directional bias in the spatial frequencies of stromal and epithelial patterns within tumor tissue. This directional bias is shown to be correlated to the pathway of reduced fluorescent tracer transport. Optical images of tumor specimens contain a complex distribution of randomly oriented aperiodic features used for neoplastic grading that varies with tumor type, size, and morphology. The internal organization of these patterns in frequency space is shown to provide a precise fingerprint of the extracellular matrix complexity, which is well known to be related to the …