Engineering Commons^™

Optimizing Sample Collection And Data Interpretation For Effective Wastewater-Based Epidemiology In Combined Sewer Systems, Christopher Allen Anderson

Graduate Theses, Dissertations, and Problem Reports

COVID-19 has spurred growth in the science surrounding wastewater-based epidemiology (WBE) pertaining to the detection of severe acute respiratory virus 2 (SARS-CoV-2) in waste streams as an early warning signal for public health. However, the highly variable wastewater environment has made it difficult to standardize an approach for sampling and analysis, especially in locations using combined sewer infrastructure. This study addresses knowledge gaps of WBE via three specific aims: (1) to compare diurnal fluctuations of SARS-CoV-2 and the human fecal indicator, pepper mild mottle virus (PMMoV) in wastewater treatment plant (WWTP) influent samples collected during dry versus wet weather conditions; …

Material Characterization Of Thermoplastic Polyurethane (Tpu) And Thermoplastic Elastomers (Tpe) For Development Of 3d-Printed Surrogate Organs For Medical Training, Anastasia Elizabeth Lucci

Graduate Theses, Dissertations, and Problem Reports

Cadaveric specimens are a necessary, albeit limited, resource for training medical students on basic surgical skills. The availability of surrogate 3D-printed organs would readily allow access to resources that could reduce or potentially eliminate the need for cadaveric specimens or, at a minimum, provide students the opportunity to practice with 3D-printed surrogates before transitioning to those specimens. This research focuses on determining which thermoplastic material most closely mimics mechanical properties such as hardness and stiffness of human organs and allows 3D printing surrogate organs to be used as safe, educational tools. Relatively “soft” materials such as thermoplastic polyurethanes (TPU) and …

Advancing Medical Technology For Motor Impairment Rehabilitation: Tools, Protocols, And Devices, Matthew Yough

Graduate Theses, Dissertations, and Problem Reports

Excellent motor control skills are necessary to live a high-quality life. Activities such as walking, getting dressed, and feeding yourself may seem mundane, but injuries to the neuromuscular system can render these tasks difficult or even impossible to accomplish without assistance. Statistics indicate that well over 100 million people are affected by diseases or injuries, such as stroke, Parkinson’s Disease, Multiple Sclerosis, Cerebral Palsy, peripheral nerve injury, spinal cord injury, and amputation, that negatively impact their motor abilities. This wide array of injuries presents a challenge to the medical field as optimal treatment paradigms are often difficult to implement due …

A Machine Learning Approach For Early Diagnosis Of Transthyretin Amyloid Cardiomyopathy Among Heart Failure Patients, Tanjim Ahmed

Graduate Theses, Dissertations, and Problem Reports

Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is a rare, progressive, and fatal disease. Prevalence of ATTR-CM ranges from 4 to 17 per 100000 cases where the mean survival time is less than 4 years. It has a history of being underdiagnosed and misdiagnosed. The diagnosis delay has a weighted mean of 6.1 years for wild-type ATTR-CM. Low awareness, the necessity of invasive procedures, and lack of treatment are the key reasons for delayed diagnosis. But, with the introduction of non-invasive tests like nuclear scintigraphy with ^99mTC-PYP and the disease modifying drug Tafamidis, the diagnosis delay signifies a missed opportunity to increase …

Longitudinal Oxygen Imaging In 3d (Bio)Printed Models, Ryan Curtis O'Connell

Graduate Theses, Dissertations, and Problem Reports

Electron paramagnetic resonance (EPR), and its molecular imaging modality, is a powerful tool to noninvasively map various biological and chemical markers within objects of interest. Reliable data acquisition is a major impeding factor for longitudinal hands-off measurements. Measurements are especially challenging in biomedical applications, as live objects are not static. Frequent changes occur that require constant fine recalibration of the EPR detection system, called the resonator. To enable longitudinal imaging, a technology permitting automatic digital control of resonator coupling, tuning, and EPR data acquisition was developed. Automation was achieved through the utilization of a microcontroller and digital peripheral components such …

A Novel Computational Network Methodology For Discovery Of Biomarkers And Therapeutic Targets, Qing Ye

Graduate Theses, Dissertations, and Problem Reports

Lung cancer has the second highest cancer incidence rate and the top cancer-related mortality worldwide. An estimate from the American Cancer Society shows that, in 2022, there will be about 236,740 lung cancer cases (117,910 men and 118,830 women) in the US. To date, there are no prognostic/predictive biomarkers to select chemotherapy, immunotherapy, and radiotherapy in individual non-small cell lung cancer (NSCLC) patients. There is an unmet clinical need to identify patients with early-stage NSCLC who are likely to develop recurrence and to predict their therapeutic responses. This dissertation developed a novel computational methodology for modeling molecular gene association networks …

Developing Artificial Intelligence Tools To Investigate The Phenotypes And Correlates Of Chronic Kidney Disease Patients In West Virginia, Marzieh Amiri Shahbazi

Graduate Theses, Dissertations, and Problem Reports

ABSTRACT

Developing Artificial Intelligence tools to investigate the phenotypes and correlates of Chronic Kidney Disease patients in West Virginia

Marzieh Amiri Shahbazi

Chronic kidney disease (CKD) is responsible for disrupting the lives of 37 million people just in the USA, which is about 1 in 7 adults. CKD results in a gradual loss of kidney function over time. Sometimes CKD doesn’t produce any significant symptoms until it reaches an advanced stage. On the other hand, acute kidney injury (AKI) accounts for a sudden decline in the kidney’s function. As a result, the kidneys fail to filter waste materials from the …

Biomechanically Inspired Assistive Technology To Restore Movement Of The Upper Limbs After Stroke, Ariel Thomas

Graduate Theses, Dissertations, and Problem Reports

A stroke often damages the neural structures responsible for movement. Stroke is a heterogeneous disease, affecting each survivor differently. There are common motor features of a stroke, but even these features vary across time as an individual proceeds through different stages of recovery. The different ways in which stroke motor impairment can present itself are often overlooked, but these differences are fundamental to the understanding of the disease and its recovery. When motor assessments are capable of acquiring information necessary to parse out a detailed profile of each stroke case, this will lead to an improved neuromechanical understanding of the …

Performance Study Of Five Different Cabin Air Filters In The Laboratory And On-Road Drive, Fahad Alqahtani

Graduate Theses, Dissertations, and Problem Reports

One of the aims of installing ventilation filters in a car is to prevent vehicle occupants from inhaling potentially harmful aerosols emanating from the environment. Vehicle cabin filters are essential in ensuring that a vehicle's air conditioning system provides clean air to its occupants. The purpose of the cabin filter is to improve air quality inside the car to provide better comfort and better protect occupants from experiencing unwanted respiratory problems. Using cabin filters in air conditioning systems is a common practice in modern vehicle manufacturing. Scientists and engineers are continually seeking new ways of improving the efficiency and effectiveness …

Green Completion As A Mitigation For Btex Exposure In Gas Flaring: Nigeria Case Study (Exposure Assessment And Cost Model), Akintunde S. Akinyemi

Graduate Theses, Dissertations, and Problem Reports

Gas flaring is an essential part of the oil and gas industry safety and waste management procedures; however, it presents a potential exposure to BTEX compounds, a group of Non-Methane Volatile Organic Compounds (NMVOC), within up to a 10-mile radius of the flare point. The physical and the psychological cost of the journey to work, make employees live close to the workplace. This study examined the perceived exposure of oil and gas industry workers to possible carcinogenic emissions outside the workplace. It looked at the outcomes of the exposure to BTEX through gas flaring drawing on archival data and using …

Evaluation Of Control Strategies For Overhead Work Using Electromyography Of Rotator Cuff Muscles, Hossein Motabar

Graduate Theses, Dissertations, and Problem Reports

Work-related musculoskeletal disorders (MSDs) of shoulder have a significant impact on overall health and economics in the industrialized nations. Rotator cuff is the most frequently injured region in the shoulder complex. Overhead work is considered as one of the most predominant causes of rotator cuff injuries. The workers in construction, automotive, and aerospace industries are routinely exposed to overhead exertions. Elimination of overhead work is nearly impossible due to various task and technology constraints. Therefore, appropriate intervention strategies based on the engineering and administrative controls opt to be used to prevent the hazardous impact of overhead exertions. The objective of …

Performance Study Of An Unconventional Breathresponse Papr Against A N95 Ffr And Conventional Paprs, Huihui Yang

Graduate Theses, Dissertations, and Problem Reports

Healthcare workers (HCWs) are the first responders when infectious pathogens occur. Powered air-purifying respirators (PAPRs) are one of the most widely used personal protective equipment for healthcare workers. Currently, few studies have been performed with HCWs in the actual healthcare work environments to assess discomforts, acceptance and protective efficiency towards wearing and use of PAPRs. The main purpose of this dissertation was to introduce and assess a brand new unconventional PAPR (Koken breath-response PAPR). The protection performance and user preferance of this unconventional PAPR were studided and compared to that of a N95 FFR and traditional PAPRs.

Firstly, a laboratory …

A Biomimetic Approach To Controlling Restorative Robotics, Matthew T. Boots

Graduate Theses, Dissertations, and Problem Reports

Movement is the only way a person can interact with the world around them. When trauma to the neuromuscular systems disrupts the control of movement, quality of life suffers. To restore limb functionality, active robotic interventions and/or rehabilitation are required. Unfortunately, the primary obstacle in a person’s recovery is the limited robustness of the human-machine interfaces. Current systems rely on control approaches that rely on the person to learn how the system works instead of the system being more intuitive and working with the person naturally. My research goal is to design intuitive control mechanisms based on biological processes termed …

Analysis Of User Preference With N95 And Powered Air-Purifying Respirators In A Healthcare Work Environment, Brittany Renee Carver

Graduate Theses, Dissertations, and Problem Reports

For those working in the healthcare field, personal protective equipment is vital. Healthcare workers are often first responders when it comes to dealing with patients who are infected or when a disease outbreak occurs. The Occupational Safety and Health Administration (OSHA) requires all healthcare operations to provide employee protection against blood borne pathogens. With the increase of life-threatening disease outbreaks, such as SARS in 2003 and Ebola in 2014, it is of the upmost importance to make sure respirators are best suited for users and acceptable for long term use. It has been shown through previous studies that due to …