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Computational Analysis And Classification Of Shg Images Of Cancerous Pancreatic Tissue Based On Collagen Fiber Alignment, Gerren Welch
Computational Analysis And Classification Of Shg Images Of Cancerous Pancreatic Tissue Based On Collagen Fiber Alignment, Gerren Welch
Honors College
Pancreatic cancer is a deadly disease, with a low five-year survival rate partly due to the difficulty in diagnosing the cancer early in its development, as it shares symptoms with more common and less lethal conditions. Using Second Harmonic Generation (SHG) microscopy and computer analysis, our knowledge of the biophysics of the pancreatic tumor microenvironment increases which may lead to the development of more effective therapies. In collaboration with Maine Medical Center Research Institute (MMCRI), we have identified 20 pancreatic cancer patients. In these 20 pancreatic cancer patients, Dr. Jones, a pathologist at MMCRI has identified normal adjacent pancreas, fibrotic …
Development Of Porous Polymeric Implants For Use In Orthopedic Research And Development Applications, Alexander Caddell
Development Of Porous Polymeric Implants For Use In Orthopedic Research And Development Applications, Alexander Caddell
Honors College
Current orthopedic implants comprised of plastic, ceramic, or metal alloys are susceptible to surface degradation at the implant-implant interface. The resulting microscopic fragments cause tissue irritation that can lead to osteolysis. In addition, existing percutaneous implants, such as pins used to stabilize fractures, are prone to bacterial infections due to the inability of the surrounding soft tissue to adhere to the implant and form a biologic seal. The goal of this Honors Thesis was to develop porous polymeric implants for orthopedic research and development applications that improve upon current designs in an attempt to remedy the issues detailed above. A …