Engineering Commons^™

Multiple Path Particle Dosimetry For Prediction Of Mouse Lung Deposition Of Nanoaerosol Particles, Mohammed Ali

Mohammed Ali

Nanoaerosolized particle (dia.<200 >nm) antibiotic inhalation therapy was tested to treat pneumonic tularemia in mice caused by Francisella novicida infection. Very limited experimental techniques are available to properly estimate inhaled doses and distribution of the drug inside the mouse lungs. To overcome this problem, computational simulation of particle deposition based on the Multiple Path Particle Dosimetry (MPPD) model was employed to simulate in vivo experimental conditions which included nasal breathing with whole body exposure to the antibiotic in the form of nano-aerosolized medicine. The deposition results were compared with several in vivo experimental data reported in literature; and satisfactory agreements …

Effects Of Three Dry Powder Inhalers On Deposition Of Aerosolized Medicine In The Human Oral-Pharyngeal-Laryngeal Regions, Mohammed Ali

Mohammed Ali

The dry powder inhaler (DPI) is a popular, effective and convenient drug delivery device for inhalation therapy to treat asthma. However, a large quantity (approximately 54%) of inhaled aerosols deposit in the oropharyngeal region. Deposition in this region is undesirable because it provides minimum therapeutic benefits and has adverse localized or systemic side effects. This study reports a method of examining electrostatic charge effects on deposition of three DPI aerosols (Spiriva^™ Handihaler, Advair Diskus^™, and Pulmicort^™ Turbohaler) in a cadaver-based cast of the human oral-pharyngeal-laryngeal (OPL) regions. Experimental aerosols were generated from the three commercially available …

"Being Mindful" And Becoming A "Harmony Worker" During Unsettling Times.Docx

Carroy U "Cuf" Ferguson, Ph.D.

Shining A Humanistic Light On Racism.Docx

Carroy U "Cuf" Ferguson, Ph.D.

Reimagining Icarus: Ethics, Law And Policy Considerations For Commercial Human Spaceflight, Sara M. Langston

Sara Langston

Commercial human spaceflight presents an area for engaging novel human activity and objectives, to include space exploration, entertainment, transportation and extraterrestrial resource acquisition. The inherent dangers and lack of scientific and medical certainty involved however raise interrelated questions of ethics, bioethics, law and public policy. This is particularly the case with spaceflight participant (SFP) screening, selection, and commercial human spaceflight activities where regulations are currently silent or lacking. In the absence of established law, ethics can play an important role by informing industry standards, policies and best practices. Understanding the fundamental ethical values at stake in the application of new …

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Investigation Of Zebrafish Larvae Behavior As Precursor For Suborbital Flights: Feasibility Study, Pedro Llanos, Kristina Andrijauskaite, Mark Rubinstein, Sherine S.L. Chan

Pedro J. Llanos (www.AstronauticsLlanos.com)

Physics Considerations In Targeted Anticancer Drug Delivery By Magnetoelectric Nanoparticles, Emmanuel Stimphil, Abhignyan Nagesetti, Rakesh Guduru, Tiffanie Stewart, Alexandra Rodzinski, Piang Liang, Sakhrat Khizroev

Sakhrat Khizroev

In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However, unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of …

Multiferroic Coreshell Magnetoelectric Nanoparticles As Nmr Sensitive Nanoprobes For Cancer Cell Detection, Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina U. Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev

Sakhrat Khizroev

Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves …

Preparation, Modification, Characterization, And Biosensing Application Of Nanoporous Gold Using Electrochemical Techniques, Jay Bhattarai, Dharmendra Neupane, Bishal Nepal, Vasilii Mikhaylov, Alexei Demchenko, Keith Stine

Alexei Demchenko

Effect Of Exercise Dosages On Adiposity Indices In Overweight Girls, Stephanie Kellam, Norma Olvera, Patrick Leung, Jian Liu, Dennis Smith

Jian Liu

Objective. The primary purpose of this study was to determine the impact of two exercise dosages on reducing adiposity in minority girls. Materials and methods. Sixty-two overweight Hispanic and African-American girls participated in one of two intense summer interventions in Houston, TX: Intervention A (exposure to about 40 hours physical activities) or Intervention B (exposure to 60 hours of physical activities). Adiposity indices (percent body fat, waist circumference, body mass index) were taken pre- and post-intervention.

Results.

Intervention B had a significantly greater decrease in adiposity indicators (p= 0.006) when compared to Intervention A. Waist circumference displayed the most significant …

Automatic Detection Of Slip-Induced Backward Falls, Jian Liu, Thurmon E. Lockhart

Jian Liu

Falls are the leading cause of injury deaths among people 65 years and older. The National Safety Council reported that in 2005, 17,700 Americans met their death by falling, and of these deaths, the majority (over 80%) were people over 65 years of age [1]. It is certainly desirable to avoid the fall accidents altogether through developing a comprehensive fall prevention program [2]. However, in case of unavoidable falls, an effective injury-prevention technology is critical to minimize/reduce fall-related physical injuries. Recently, the concept of wearable airbag [3] emerged as one viable and promising injury-prevention approach.

Analysis Of Gait Characteristics In Mentally Handicapped Individuals, Prakriti Parijat, Jian Liu, Thurmon E. Lockhart, Courtney Haynes

Jian Liu

Physical and motor dysfunctions in mentally handicapped individuals predispose them to a higher risk of slip and fall accidents. It is estimated that over 60 million people are currently suffering with some level of developmentally related cognitive impairment (American Disability Act ADA, 2000). Mental retardation occurs in 2.5-3% of the general population. About 6-7.5 million mentally retarded individuals live in the United States alone (ADA, 2000). Slip induced fall accidents are a primary source of injury in people with mental retardation (MR). Often, the incidence of falls among this population is compounded by other disabilities such as autism, seizure, and …

Ransomware In Healthcare Facilities: The Future Is Now, Nikki Spence, David P. Paul Iii, Alberto Coustasse

Alberto Coustasse, DrPH, MD, MBA, MPH

Cybercriminals have begun to target the healthcare industry with a type of malware called ransomware, malware that encrypts an infected device and any attached devices or network drives. After encryption, cybercriminals demand a sum of money, also known as a “ransom,” to release the devices from encryption. Without adequate disaster recovery and backup plans, many businesses are forced to pay the ransom. The purpose of this study was to determine the extent of recent ransomware infections in healthcare settings, the risk liabilities and cost associated with such infections, and to determine possible risk mitigation tactics. Financial costs associated with business …

Emg And Kinematic Responses To Unexpected Slips After Slip Training In Virtual Reality, Prakriti Parijat, Thurmon E. Lockhart, Jian Liu

Jian Liu

The objective of the study was to design a virtual reality (VR) training to induce perturbation in older adults similar to a slip and examine the effect of the training on kinematic and muscular responses in older adults. Twenty-four older adults were involved in a laboratory study and randomly assigned to two groups (VR training and control). Both groups went through three sessions including baseline slip, training, and transfer of training on slippery surface. The training group experienced 12 simulated slips using a visual perturbation induced by tilting a VR scene while walking on the treadmill and the control group …

The Girl Scout Climbing Wall Multidisciplinary Service-Learning Project, Margaret Pinnell, Corinne M. Daprano, Gabrielle Williamson

Corinne M. Daprano

The Girl Scout Wall (GS Wall) project was implemented in two classes at the University of Dayton (UD): a Mechanical and Aerospace Engineering (MAE) course, and a Health and Sports Science (HSS) course, and Sport Facility Management. The MAE course, Introduction to Materials, is a three-credit, third-year required course where students learn about the basic structure and properties of materials as well as the principles of material selection. The Sport Facility Management course is a three-semester hour, required HSS course where students are introduced to the processes of planning, constructing, equipping, maintaining, and managing sport facilities.

Hispanic Maternal And Children's Perceptions Of Neighborhood Safety Related To Walking And Cycling, Norma Olvera, Dennis W. Smith, Chanam Lee, Jian Liu, Jay Lee, Stephanie Kellam, Jun-Hyun Kim

Jian Liu

This study examined neighborhood safety as perceived by children (mean age=10 years) and their mothers, and its association with children's physical activity. For all eight safety items examined, children perceived their environment as less dangerous than mothers (p<0.05). None of the multiple regression models predicting children's physical activity by safety perceptions were significant (p>0.10). The maternal perception model explained the highest percentage of variance (R2=0.26), compared to the children's perception model (R2=0.22). Findings suggest that future studies should explore relations between self-reported and objectively measured safety barriers to Hispanic youth walking and cycling.

A Review Focujsed On The Psychological Effectiveness Of Tai Chi On Different Populations, Long Zhang, Thomas Lowder, Jian Liu

Jian Liu

No abstract provided.

Local Dynamic Stability Associated With Load Carrying, Jian Liu, Thurmon E. Lockhart

Jian Liu

Objectives: Load carrying tasks are recognized as one of the primary occupational factors leading to slip and fall injuries. Nevertheless, the mechanisms associated with load carrying and walking stability remain illusive. The objective of the current study was to apply local dynamic stability measure in walking while carrying a load, and to investigate the possible adaptive gait stability changes. Methods: Current study involved 25 young adults in a biomechanics research laboratory. One tri-axial accelerometer was used to measure three-dimensional low back acceleration during continuous treadmill walking. Local dynamic stability was quantified by the maximum Lyapunov exponent (maxLE) from a nonlinear …

Aging Effect On Foot Dynamics During Unexpected Slips, Jian Liu, Thurmon E. Lockhart

Jian Liu

Slip-induced fall accidents have been recognized as a serious threat to the health of the elderly.The objective of the current study was to investigate the aging effect on the biomechanical reactions of both perturbed foot and unperturbed foot to the unexpected slips. Nineteen younger (mean age: 25.0 years old) and twenty-one older (mean age: 71.2 years old) adults were involved in a laboratory study,in which slippery surface was induced during walking without their awareness.The reactive responses of both slipping foot and unperturbed foot were quantified by optical motion capture system and force platforms.The results indicate a characteristic toe-touch strategy by …

Use Of Imaging Biomarkers To Assess Perfusion And Glucose Metabolism In The Skeletal Muscle Of Dystrophic Mice, Nabeel Ahmad, Ian Welch, Robert Grange, Jennifer Hadway, Savita Dhanvantari, David Hill, Ting-Yim Lee, Lisa M Hoffman

Lisa Hoffman

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe neuromuscular disease that affects 1 in 3500 boys. The disease is characterized by progressive muscle degeneration that results from mutations in or loss of the cytoskeletal protein, dystrophin, from the glycoprotein membrane complex, thus increasing the susceptibility of contractile muscle to injury. To date, disease progression is typically assessed using invasive techniques such as muscle biopsies, and while there are recent reports of the use of magnetic resonance, ultrasound and optical imaging technologies to address the issue of disease progression and monitoring therapeutic intervention in dystrophic mice, our study aims to validate …

Jessicahlawrencemastersportfolio.Pdf, Jessicah Lawrence

Jessicah Lawrence

No abstract provided.

Enhancing Informative Frame Filtering By Water And Bubble Detection In Colonoscopy Videos, Ashok Dahal, Junghwan Oh, Wallapak Tavanapong, Johnny S. Wong, Piet C. De Groen

Johnny Wong

Colonoscopy has contributed to a marked decline in the number of colorectal cancer related deaths. However, recent data suggest that there is a significant (4-12%) miss-rate for the detection of even large polyps and cancers. To address this, we have been investigating an ‘automated feedback system’ which informs the endoscopist of possible sub-optimal inspection during colonoscopy. A fundamental step of this system is to distinguish non-informative frames from informative ones. Existing methods for this cannot classify water/bubble frames as non-informative even though they do not carry any useful visual information of the colon mucosa. In this paper, we propose a …

Cable Footprint History: Spatio-Temporal Technique For Instrument Detection In Gastrointestinal Endoscopic Procedures, Chuanhai Zhang, Wallapak Tavanapong, Johnny S. Wong, Piet C. De Groen, Junghwan Oh

Johnny Wong

We propose a new fast spatio-temporal technique that detects an operation scene---a video segment corresponding to a single purpose diagnosis action or a single purpose therapeutic action. The technique utilizes (1) color contrast of the cable region and the background, (2) the new area-based coordinate system to compute spatial features, and (3) the history of locations of detected cables of the instrument in a video to discard false regions. The proposed technique and software are useful for (1) automatic documentation of diagnostic or therapeutic operations at the end of the procedure, (2) a second review for causes of complications due …

Recombinant Aav Serotype And Capsid Mutant Comparison For Pulmonary Gene Transfer Of Alpha-1-Antitrypsin Using Invasive And Noninvasive Delivery, Rejean Liqun Wang, Thomas J. Mclaughlin, Travis Cossette, Qiushi Tang, Kevin Foust, Martha Campbell-Thompson, Ashley Martino, Pedro Cruz, Scott Loiler, Christian Mueller, Terence R. Flotte

Christian Mueller

Recombinant adeno-associated viral (rAAV) vectors have been widely used in pulmonary gene therapy research. In this study, we evaluated the transduction and expression efficiencies of several AAV serotypes and AAV2 capsid mutants with specific pulmonary targeting ligands in the mouse lung. The noninvasive intranasal delivery was compared with the traditional intratracheal lung delivery. The rAAV8 was the most efficient serotype at expressing alpha-1-antitrypsin (AAT) in the lung among all the tested serotypes and mutants. A dose of 1 x 1010 vg of rAAV8-CB-AAT transduced a high percentage of cells in the lung when delivered intratrachealy. The serum and the broncho-alveolar …

An Investigation Of Quality Climate And Its Association With Implementation Of Quality Management System, Sai K. Ramaswamy, Gretchen A. Mosher

Sai Ramaswamy

Quality management and continuous improvement are paramount for businesses to survive and thrive in today’s competitive landscape (Goetsch & Davis, 2003; Abdullah et al., 2009). One effective approach to operationalize quality processes and continuous improvement goals is a formalized quality management system (Khanna et al., 2010; Mosher et al., 2013). Quality management systems are embodiments of the organization’s policies, procedures, plans, resources, processes and delegation of responsibility and authority designed to achieve customer satisfaction within the boundaries of organizational objectives (Goetsch & Davis, 2003). While these systems are being used extensively across many industries, the ideas are relatively new to …

Approaching Safety Through Quality: Factors Influencing College Student Perceptions, Sai K. Ramaswamy, Gretchen A. Mosher

Sai Ramaswamy

Quality management practices have been identified by previous literature as a factor that could potentially reduce the level of safety incidents and hazards in agricultural work environments. The present study used multivariate analysis to examine the effect of independent variables such as quality and safety awareness, work experience, safety and quality management experience, and the perceived importance of safety and quality on the role of quality management practices as a mitigating factor for safety hazards and incidents in agriculture. Variables were measured on a five-point scale using a survey questionnaire. Data were collected from approximately 900 undergraduates enrolled in the …

Perceptions Of Agricultural College Students On The Relationship Between Quality And Safety In Agricultural Work Environments, Sai K. Ramaswamy, Gretchen A. Mosher

Sai Ramaswamy

Agriculture is a high-hazard industry that employs a large number of young workers below the age of 25. Recent studies have documented a strong positive correlation between quality management in agriculture and occupational safety as perceived by agricultural workers. Younger workers have been found to be at higher risk for occupational injuries and fatalities in agriculture. Furthermore, college students in agriculture have minimal exposure to safety and quality management principles in their coursework and thus may not be aware that the two concepts are associated. Little research has studied how young workers perceive the relationship between safety and quality and …

Deriving An Indoor Environmental Index For Portuguese Office Buildings, João F. Gomes

João F Gomes

No abstract provided.