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Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe
Quantitative Yttrium-90 Bremsstrahlung Spect/Ct And Pet/Ct Study For 3d Dosimetry In Radiomicrosphere Therapy, Senait Aknaw Debebe
FIU Electronic Theses and Dissertations
Liver cancer ranks the third most common cause of cancer related mortality worldwide. Radiomicrosphere therapy (RMT), a form of radiation therapy, involves administration of Yttrium-90 (90Y) microspheres to the liver via the hepatic artery. 90Y microspheres bremsstrahlung SPECT/CT or PET/CT imaging could potentially identify an extrahepatic uptake. An early detection of such an uptake, thus, could initiate preventative measures early on. However, the quantitative accuracy of bremsstrahlung SPECT/CT images is limited by the wide and continuous energy spectrum of 90Y bremsstrahlung photons. 90Y PET/CT imaging is also possible but limited by the extremely small internal pair production decay. These limitation …
Multiferroic Coreshell Magnetoelectric Nanoparticles As Nmr Sensitive Nanoprobes For Cancer Cell Detection, Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina U. Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev
Multiferroic Coreshell Magnetoelectric Nanoparticles As Nmr Sensitive Nanoprobes For Cancer Cell Detection, Abhignyan Nagesetti, Alexandra Rodzinski, Emmanuel Stimphil, Tiffanie Stewart, Chooda Khanal, Ping Wang, Rakesh Guduru, Ping Liang, Irina U. Agoulnik, Jeffrey Horstmyer, Sakhrat Khizroev
Electrical and Computer Engineering Faculty Publications
Magnetoelectric (ME) nanoparticles (MENs) intrinsically couple magnetic and electric fields. Using them as nuclear magnetic resonance (NMR) sensitive nanoprobes adds another dimension for NMR detection of biological cells based on the cell type and corresponding particle association with the cell. Based on ME property, for the first time we show that MENs can distinguish different cancer cells among themselves as well as from their normal counterparts. The core-shell nanoparticles are 30 nm in size and were not superparamagnetic. Due to presence of the ME effect, these nanoparticles can significantly enhance the electric field configuration on the cell membrane which serves …
Physics Considerations In Targeted Anticancer Drug Delivery By Magnetoelectric Nanoparticles, Emmanuel Stimphil, Abhignyan Nagesetti, Rakesh Guduru, Tiffanie Stewart, Alexandra Rodzinski, Piang Liang, Sakhrat Khizroev
Physics Considerations In Targeted Anticancer Drug Delivery By Magnetoelectric Nanoparticles, Emmanuel Stimphil, Abhignyan Nagesetti, Rakesh Guduru, Tiffanie Stewart, Alexandra Rodzinski, Piang Liang, Sakhrat Khizroev
Electrical and Computer Engineering Faculty Publications
In regard to cancer therapy, magnetoelectric nanoparticles (MENs) have proven to be in a class of its own when compared to any other nanoparticle type. Like conventional magnetic nanoparticles, they can be used for externally controlled drug delivery via application of a magnetic field gradient and image-guided delivery. However, unlike conventional nanoparticles, due to the presence of a non-zero magnetoelectric effect, MENs provide a unique mix of important properties to address key challenges in modern cancer therapy: (i) a targeting mechanism driven by a physical force rather than antibody matching, (ii) a high-specificity delivery to enhance the cellular uptake of …