Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Microfluidics Design Considering Hyperuniformity And Cell Transport In Flow For Improved Circulating Tumor Cell Capture Efficiency, Michael Clarence Hood
Graduate Research Theses & Dissertations
Isolation of circulating tumor cells (CTCs) from patient derived blood samples for cancerdiagnostics and monitoring is challenging due to the extremely low CTC concentration. This thesis work evaluates the performance of passive microfluidics devices with different designs based on computational modeling. A new cell separation method is proposed based on velocity differentiation of varying cell sizes. All numerical studies were conducted in 2D based on a fluid structure interaction code where the fluid flow was solved based on the lattice Boltzmann method (LBM) implemented in Palabos, and the cell dynamics were simulated based on the molecular dynamics package LAMMPS, with …