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Full-Text Articles in Engineering
The Study Of 3d Micro-Fluid Printing In Aqueous Two-Phase System, Mian Huang
The Study Of 3d Micro-Fluid Printing In Aqueous Two-Phase System, Mian Huang
Dissertations and Theses
Aqueous two-phase system (ATPS) is a technology that allows phase separation in an aqueous environment. This technology can be used for the separation, extraction and purification of a variety of biomolecules and thus gained great attention in industry and academia. This thesis is a combination of ATPS, 3D printing, and microfluidics technologies and realizes the printing of biocompatible aqueous structures in another aqueous matrix. The objectives of this thesis include 1) customizing a regular thermal extrusion 3D printer for printing 3D aqueous structures, 2) printing 3D aqueous structure in an aqueous matrix, and 3) studying the stability of the printed …
Passive Separation Of Binary Fluid Mixtures In Microchannels Using Lattice Boltzmann Method, Mohanad Kamil Radhi
Passive Separation Of Binary Fluid Mixtures In Microchannels Using Lattice Boltzmann Method, Mohanad Kamil Radhi
Dissertations and Theses
Fluid mixtures in real life exist in two forms: miscible and immiscible. Separation of these mixtures using chemical agents or thermal energy has both environmental and economic disadvantages. The high cost and the environmental damage caused by the traditional separation techniques have stimulated both academia and industry to seek alternatives. The emergence of microfluidics offers robust solutions for a broad span of transport problems due to the high surface to volume ratio and reduced length scales. Particularly, the separation efficiency increases significantly due to the aforementioned feature. However, there is still a pressing need of passive separations for the sake …
Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien
Developing A 3d In Vitro Model By Microfluidics, Hung-Ta Chien
Dissertations and Theses
In vitro tissue models play an important role in providing a platform that mimics the realistic tissue microenvironment for stimulating and characterizing the cellular behavior. In particular, the hydrogel-based 3D in vitro models allow the cells to grow and interact with their surroundings in all directions, thus better mimicking in vivo than their 2D counterparts. The objective of this thesis is to establish a 3D in vitro model that mimics the anatomical and functional complexity of the realistic cancer microenvironment for conveniently studying the transport coupling in porous tissue structures. We pack uniform-sized PEGDA-GelMA microgels in a microfluidic chip to …
Analysis Of Capillary Flow In Interior Corners : Perturbed Power Law Similarity Solutions, Joshua Thomas Mccraney
Analysis Of Capillary Flow In Interior Corners : Perturbed Power Law Similarity Solutions, Joshua Thomas Mccraney
Dissertations and Theses
The design of fluid management systems requires accurate models for fluid transport. In the low gravity environment of space, gravity no longer dominates fluid displacement; instead capillary forces often govern flow. This thesis considers the redistribution of fluid along an interior corner. Following a rapid reduction of gravity, fluid advances along the corner measured by the column length z = L(t), which is governed by a nonlinear partial differential equation with dynamical boundary conditions. Three flow types are examined: capillary rise, spreading drop, and tapered corner. The spreading drop regime is shown to exhibit column length growth L ~ …
Silk Cryogels For Microfluidics, Christopher David Hinojosa
Silk Cryogels For Microfluidics, Christopher David Hinojosa
Dissertations and Theses
Silk fibroin from silkworm cocoons is found in numerous applications ranging from textiles to medical implants. Its recent adoption as a biomaterial is due to the material's strength, biocompatibility, self-assembling behavior, programmable degradability, optical clarity, and its ability to be functionalized with antibodies and proteins. In the field of bioengineering it has been utilized as a tissue scaffolding, drug delivery system, biosensor, and implantable electrode. This work suggests a new application for porous silk in a microscale chromatography column. We demonstrate in situ cryotropic polymerization of highly porous structures in microscale geometries by freezing aqueous silk with a solvent. The …