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Full-Text Articles in Engineering
Development Of A Multi-Use Modular Microfluidic Platform Using 3d Printing, Carson Emeigh
Development Of A Multi-Use Modular Microfluidic Platform Using 3d Printing, Carson Emeigh
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Microfluidic lab-on-a-chip (LoC) technology has driven numerous innovations due to their ability to perform laboratory-scale experiments on a single chip using microchannels. Although LoC technology has been innovative, it still suffers from limitations related to its fabrication and design flexibility. Typical LoC fabrication, with photolithography, is time consuming, expensive, and inflexible. To overcome the limitations of LoC devices, modular microfluidic platforms have been developed where multiple microfluidic modules, each with a specific function or group of functions, can be combined on a single platform. Modular microfluidics have overcome some of the limitations of LoC devices, but currently, their fabrication is …
Temporally And Spatially Resolved Quantification Of Hemodynamic Forces And Endothelial Mechanics, Lori M. Lambert
Temporally And Spatially Resolved Quantification Of Hemodynamic Forces And Endothelial Mechanics, Lori M. Lambert
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
The endothelium is a thin layer of endothelial cells that line the interior surface of an artery. Due to their direct contact with blood flow, endothelial cells experience varying hemodynamic forces and respond to these forces by altering their morphology. When plaque and other substances accumulate in the walls of arteries, i.e., atherosclerosis, endothelial cells have abnormal responses to blood flow. Studying atherosclerosis progression is, therefore, a two-fold investigation into 1) the hemodynamic forces that cause endothelial responses, and 2) the biological and mechanical responses of endothelial cells. The ultimate goal of this study was to develop an experimental …
Evaluation Of The Mass Transfer Effect Of The Stalk Contraction-Relaxation Cycle Of Vorticella Convallaria, Jiazhong Zhou
Evaluation Of The Mass Transfer Effect Of The Stalk Contraction-Relaxation Cycle Of Vorticella Convallaria, Jiazhong Zhou
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Vorticella convallaria is a genus of protozoa living in fresh water. It has a bell-shaped zooid equipped with adoral ciliary bands and a contractile stalk tethering the zooid to a substrate. Vorticella is regarded as a biological spring because its contractile stalk can pull the zooid towards the substrate at a remarkably high speed and then relaxes to its extended state much more slowly. However, reasons for Vorticella’s stalk contraction are still unknown. It is presumed that the flow field induced by the contraction-relaxation cycle of Vorticella would augment mass transfer effect near the substrate. We investigated this hypothesis …