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Development Of Antimicrobial Chitosan Based Nanofiber Dressings For Wound Healing Applications, Lee Cremar, Jorge Gutierrez, Jennifer Martinez, Luis A. Materon, Robert Gilkerson, Fenghua Xu, Karen Lozano
Development Of Antimicrobial Chitosan Based Nanofiber Dressings For Wound Healing Applications, Lee Cremar, Jorge Gutierrez, Jennifer Martinez, Luis A. Materon, Robert Gilkerson, Fenghua Xu, Karen Lozano
Mechanical Engineering Faculty Publications and Presentations
Objective(s): Chitosan based composite fine fibers were successfully produced via a centrifugal spinning technology. This study evaluates the ability of the composites to function as scaffolds for cell growth while maintaining an antibacterial activity.
Materials and Methods: Two sets of chitosan fiber composites were prepared, one filled with anti-microbial silver nanoparticles and another one with cinnamaldeyhde. Chitosan powder was dissolved in trifluoroacetic acid and dichloromethane followed by addition of the fillers. The fiber output was optimized by configuring the polymer weight concentration (7, 8, and 9 w/w% chitosan) and applied angular velocity (6000-9000 RPM) within the spinning process.
Results: …