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A Pilot Study On The Nanoscale Properties Of Bone Tissue Near Lacunae In Fracturing Women, Wen Qian, Roman Schmidt, Joseph A. Turner, Sue P. Bare, Joan M. Lappe, Robert R. Recker, Mohammed P. Akhter
A Pilot Study On The Nanoscale Properties Of Bone Tissue Near Lacunae In Fracturing Women, Wen Qian, Roman Schmidt, Joseph A. Turner, Sue P. Bare, Joan M. Lappe, Robert R. Recker, Mohammed P. Akhter
Department of Mechanical and Materials Engineering: Faculty Publications
The goal of this study is to investigate the causes of osteoporosis-related skeletal fragility in postmenopausal women. We hypothesize that bone fragility in these individuals is largely due to mineral, and/or intrinsic material properties in the osteocyte lacunar/peri-lacunar regions of bone tissue. Innovative measurements with nanoscale resolution, including scanning electron microscope (SEM), an atomic force microscope that is integrated with infrared spectroscopy (AFM-IR), and nanoindentation, were used to characterize osteocyte lacunar and peri-lacunar properties in bone biopsies from fracturing (Cases) and matched (Age, BMD), non-fracturing (Controls) postmenopausal healthy women. In the peri-lacunar space, the nanoindentation results show that the modulus …