Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
The Influence Of 3d Porous Chitosan-Alginate Biomaterial Scaffold Properties On The Behavior Of Breast Cancer Cells, Minh-Chau N. Le
The Influence Of 3d Porous Chitosan-Alginate Biomaterial Scaffold Properties On The Behavior Of Breast Cancer Cells, Minh-Chau N. Le
Honors Undergraduate Theses
The tumor microenvironment plays an important role in regulating cancer cell behavior. The tumor microenvironment describes the cancer cells, and the surrounding endothelial cells, fibroblasts, and mesenchymal stem cells, along with the extracellular matrix (ECM). The tumor microenvironment stiffens as cancer undergoes malignant progression, providing biophysical cues that promote invasive, metastatic cellular behaviors. This project investigated the influence of three dimensional (3D) chitosan-alginate (CA) scaffold stiffness on the morphology, growth, and migration of green fluorescent protein (GFP) – transfected MDA-MB-231 (231-GFP) breast cancer (BCa) cells. The CA scaffolds were produced by the freeze casting method at three concentrations, 2 wt%, …