Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Engineering
Hemodynamic Response To Device Titration In The Shunted Single Ventricle Circulation - A Patient Cohort Modeling Study, Chet Villa, Farha Zafar, Angela Lorts, Ethan Kung
Hemodynamic Response To Device Titration In The Shunted Single Ventricle Circulation - A Patient Cohort Modeling Study, Chet Villa, Farha Zafar, Angela Lorts, Ethan Kung
Publications
Clinical outcomes of ventricular assist device (VAD) support for shunted single ventricle patients trail the larger population due in part to the challenges in optimizing VAD support and balancing systemic and pulmonary circulations. We sought to understand the response to VAD titration in the shunted circulation using a lumped-parameter network modeling six patient-specific clinical cases. Hemodynamic data from six patients (mean body surface area = 0.30 m2) with a systemic-to-pulmonary shunt was used to construct simulated cases of heart failure and hemodynamic response to increasing VAD flow from 5 to 10 L/min/m2. With increasing VAD flow, …
Design, Development And Temporal Evaluation Of An Mri-Compatible In-Vitro Circulation Model Using A Compliant Aaa Phantom, Mirunalini Thirugnanasambandam, Tejas Canchi, Senol Piskin, Christof Karmonik, Ethan Kung, Prahlad Menon, Stephanie Avril, Ender A. Finol
Design, Development And Temporal Evaluation Of An Mri-Compatible In-Vitro Circulation Model Using A Compliant Aaa Phantom, Mirunalini Thirugnanasambandam, Tejas Canchi, Senol Piskin, Christof Karmonik, Ethan Kung, Prahlad Menon, Stephanie Avril, Ender A. Finol
Publications
Biomechanical characterization of abdominal aortic aneurysms (AAA) has become commonplace in rupture risk assessment studies. However, its translation to the clinic has been greatly limited due to the complexity associated with its tools and their implementation. The unattainability of patient-specific tissue properties leads to the use of generalized population-averaged material models in finite element analyses, which adds a degree of uncertainty to the wall mechanics quantification. In addition, computational fluid dynamics modeling of AAA typically lacks the patient-specific inflow and outflow boundary conditions that should be obtained by non-standard of care clinical imaging. An alternative approach for analyzing AAA flow …