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Full-Text Articles in Engineering
Compounds And Methods For Reducing Oxidative Stress, Thomas Dziubla, J. Zach Hilt, Dipti Biswal, David B. Cochran, Paritosh Wattamwar
Compounds And Methods For Reducing Oxidative Stress, Thomas Dziubla, J. Zach Hilt, Dipti Biswal, David B. Cochran, Paritosh Wattamwar
Chemical and Materials Engineering Faculty Patents
Antioxidant polymeric compounds are provided that comprise a plurality of monomeric portions, where each monomeric portion includes an antioxidant molecule interposed between at least two acrylate molecules, and where at least one acrylate molecule of each monomeric portion is linked by a diamine molecule to an acrylate molecule of an adjacent monomeric portion to thereby form the polymer. Methods of synthesizing polymeric compounds and methods of using the antioxidant polymeric compounds to reduce oxidative stress are also provided.
Compounds And Methods For Reducing The Occurrence Of Post-Surgical Adhesions, Thomas Dziubla, Eugene Kaplan, John Mark Medley Jr.
Compounds And Methods For Reducing The Occurrence Of Post-Surgical Adhesions, Thomas Dziubla, Eugene Kaplan, John Mark Medley Jr.
Chemical and Materials Engineering Faculty Patents
Compounds and methods for reducing the occurrence of a post-surgical adhesion are provided. The compounds can include acrylic acid groups and ethylene glycol groups, and can be directed to an area of damaged tissue by the incorporation of a fibrin targeting peptide. The compounds can further include a brush-like portion, capable of creating a steric barrier between a damaged tissue or organ and adjacent tissues or organs, and a targeting portion, capable of directing the compounds to a damaged tissue or organ. Methods of detecting damaged tissue and kits are also provided.