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Full-Text Articles in Engineering
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Engineered Nanoparticles For Site-Specific Bioorthogonal Catalysis: Imaging And Therapy, Riddha Das
Doctoral Dissertations
Bioorthogonal catalysis offers a strategy for chemical transformations complementary to bioprocesses and has proven to be a powerful tool in biochemistry and medical sciences. Transition metal catalysts (TMCs) have emerged as a powerful tool to execute selective chemical transformations, however, lack of biocompatibility and stability limits their use in biological applications. Incorporation of TMCs into nanoparticle monolayers provides a versatile strategy for the generation of bioorthogonal nanocatalysts known as “nanozymes”. We have fabricated a family of nanozymes using gold nanoparticles (AuNPs) as scaffolds featuring diverse chemical functional groups for controlled localization of nanozymes in biological environments, providing unique strategies for …
Tailoring Nanoparticles And Polymers For Cooperative Interfacial And Surface Interactions, Irem Bolukbasi
Tailoring Nanoparticles And Polymers For Cooperative Interfacial And Surface Interactions, Irem Bolukbasi
Doctoral Dissertations
This thesis describes the synthesis of chemically functionalized nanoparticles and their behavior at interfaces and in conjunction with polymers. Solid-liquid, liquid-liquid, and air-liquid interfaces are useful platforms for studying nanoparticle assembly, especially when nanoparticles are functionalized to enable their segregation to the interface. At the liquid-liquid interface, double emulsions droplets, both oil-in-water-in-oil and water-in-oil-in-water, stabilized with nanoparticles were prepared. This involved gold nanoparticles stabilizing oil-in-water droplets, and CdSe quantum dots stabilizing water-in-oil droplets. These double emulsion droplets were by simply shaking to give polydisperse droplets, or in a well-defined fashion by microcapillary flow focusing. When nanoparticle-stabilized double emulsions were sized …
Functionalized Nanoparticles For Biological Imaging And Detection Applications, Bing C Mei
Functionalized Nanoparticles For Biological Imaging And Detection Applications, Bing C Mei
Doctoral Dissertations 1896 - February 2014
Semiconductor quantum dots (QDs) and gold nanoparticles (AuNPs) have gained tremendous attention in the last decade as a result of their size-dependent spectroscopic properties. These nanoparticles have been a subject of intense study to bridge the gap between macroscopic and atomic behavior, as well as to generate new materials for novel applications in therapeutics, biological sensing, light emitting devices, microelectronics, lasers, and solar cells. One of the most promising areas for the use of these nanoparticles is in biotechnology, where their size-dependent optical properties are harnessed for imaging and sensing applications. However, these nanoparticles, as synthesized, are often not stable …