Engineering Commons^™

Layer-By-Layer Self -Assembly For Enzyme And Dna Encapsulation And Delivery, Amish Patel

Doctoral Dissertations

Thin wall microcapsules were formed via Layer-by-Layer Self-Assembly of alternate adsorption of oppositely charged polyelectrolyte on microcores. After the core dissolution, empty polymeric shells with 20–25 nm thick walls were obtained. These microcapsules were loaded with Myoglobin, Hemoglobin and Glucose Oxidase by opening capsule pores at low pH and closing them at higher pH. The native structure of the enzyme was not affected due to different treatments. Biocompatible nanoshells were also prepared for encasing DNA. Using the same Layer-by-Layer Self-Assembly approach nanoparticle were constructed containing DNA as one of the layers. The nanoparticles of different architecture were used to deliver …

Computational Approaches To The Design And Analysis Of Stability Of Polypeptide Multilayer Thin Films, Bin Zheng

Doctoral Dissertations

The focus of this research is the development of computational approaches to understanding the physical basis of layer-by-layer assembly (LBL), a key methodology of nanomanufacturing. The results provided detailed information on structure which cannot be obtained directly by experiments.

The model systems chosen for study are polypeptide chains. Reasons for this are that polypeptides are no less polyelectrolytes than the more usual polyions, and one can control the primary structure of a polypeptide on a residue-by-residue basis using modern synthetic methods. Moreover, as peptides constitute one of the four major classes of biological macromolecules, research in this direction is expected …

Fabrication, Characterization, And Modeling Of Organic Capacitors, Schottky Diodes, And Field Effect Transistors, Mo Zhu

Doctoral Dissertations

The objectives of this project are to fabricate, characterize, and model organic microelectronic devices by traditional lithography techniques and Technology Computer Aided Design (TCAD).

Organic microelectronics is becoming a promising field due to its number of advantages in low-cost fabrication for large area substrates. There have been growing studies in organic electronics and optoelectronics. In this project, several organic microelectronic devices are studied with the aid of experimentation and numerical modeling.

Organic metal-insulator-metal (MIM) and metal-insulator-semiconductor (MIS) capacitors consisting of insulating polymer poly(4-vinylphenol) (PVP) have been fabricated by spin-coating, photo lithography, and reactive ion etching techniques. Based on the fabricated …