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The Kinetics And Hepatotoxicity Of Benzyl Chloride Vapor In Rats, Hari V. Rao
The Kinetics And Hepatotoxicity Of Benzyl Chloride Vapor In Rats, Hari V. Rao
Theses
Male Sprague Dawley rats (250g) were exposed to benzyl chloride vapor at a concentration of 220 ppm for 6 hours. During inhalation, the blood benzyl chloride concentration increased to reach a steady state level of 9-10 ug/ml between 4 and 6 hours of exposure. A small concentration of benzyl chloride (0.86 ug/ml) was present in the blood four hours after the termination of exposure. The absorption half life was 0.53 hours (0.39-0.81) and the elimination half life was l.12 hour (0.93-l.40).
The absorbed benzyl chloride was largely retained in the blood and some of it (0.22 ug/g) was sequestered into …