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Full-Text Articles in Engineering
Biocompatible Microchannel Scaffold With Microwires For Recording Regenerative Peripheral Nerve Neural Spikes, Manisankar Chennamsetti
Biocompatible Microchannel Scaffold With Microwires For Recording Regenerative Peripheral Nerve Neural Spikes, Manisankar Chennamsetti
Theses and Dissertations
A new process for the fabrication of a microchannel scaffold with microwires for peripheral nerve applications is presented. This microchannel scaffold implemented between the ends of nerves, the axons of which regenerate through microchannel in scaffold and fixed microelectrodes. This device is entirely handcrafted using commercially available materials such as microwires, PDMS film, liquid PDMS, dental cement, and epoxy glue. This device was implemented in the a Lewis rat sciatic nerve to better analyze the electrical signals of regenerated axons. 64-electrode microchannel scaffolds were developed for both peripheral nerve interfacing and peripheral nerve regeneration. The microwires were used for recording …
Genotoxicity Of Graphene In Escherichia Coli, Ananya Sharma
Genotoxicity Of Graphene In Escherichia Coli, Ananya Sharma
Graduate Theses and Dissertations
Rapid advances in nanotechnology necessitate assessment of the safety of nanomaterials in the resulting products and applications. One key nanomaterial attracting much interest in many areas of science and technology is graphene. Graphene is a one atom thick carbon allotrope arranged in a two-dimensional honeycomb lattice. In addition to being extremely thin, graphene has several extraordinary physical properties such as its exceptional mechanical strength, thermal stability, and high electrical conductivity. Graphene itself is relatively chemically inert and therefore pristine graphene must undergo a process called functionalization, which is combination of chemical and physical treatments that change the properties of graphene, …
Handcrafted Electrocorticography Electrodes For A Rodent Neural Activity, Nishat Tasnim
Handcrafted Electrocorticography Electrodes For A Rodent Neural Activity, Nishat Tasnim
Theses and Dissertations
Electrocorticography (ECoG) is a minimally invasive neural recording method that has been extensively used for neuroscience applications. Although many neural recording methods exist, ECoG provides a combination of stability, high spatial and temporal resolution with chronic and mobile capabilities. This paper presents an animal study using a low cost and simple handcrafted ECoG electrode that is made of commercially accessible materials. The study is performed on a Lewis rat implanted with a handcrafted 32-channel non-penetrative ECoG electrode covering an area of 3 x 3 mm 2 on the cortical surface. The ECoG electrodes were placed on the motor and somatosensory …
Microwire Regenerative Peripheral Nerve Interfaces With Wireless Recording And Stimulation Capabilities, Ali Ajam
Theses and Dissertations
A scalable microwire peripheral nerve interface was developed, which interacted with regenerated peripheral nerves in microchannel scaffolds. Neural interface technologies are envisioned to facilitate direct connections between the nervous system and external technologies such as limb prosthetics or data acquisition systems for further processing. Presented here is an animal study using a handcrafted microwire regenerative peripheral nerve interface, a novel neural interface device for communicating with peripheral nerves. The neural interface studies using animal models are crucial in the evaluation of efficacy and safety of implantable medical devices before their use in clinical studies.16-electrode microwire microchannel scaffolds were developed for …
Experimental And Computational Studies Of Cortical Neural Network Properties Through Signal Processing, Wesley Patrick Clawson
Experimental And Computational Studies Of Cortical Neural Network Properties Through Signal Processing, Wesley Patrick Clawson
Graduate Theses and Dissertations
Previous studies, both theoretical and experimental, of network level dynamics in the cerebral cortex show evidence for a statistical phenomenon called criticality; a phenomenon originally studied in the context of phase transitions in physical systems and that is associated with favorable information processing in the context of the brain. The focus of this thesis is to expand upon past results with new experimentation and modeling to show a relationship between criticality and the ability to detect and discriminate sensory input. A line of theoretical work predicts maximal sensory discrimination as a functional benefit of criticality, which can then be characterized …