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Synergisms Of Electric Or Electromagnetic Fields And Photodynamic Effects Induce Apoptosis And Necrosis Of Cancer Cells, Radeva Maria, Lambrera Maya, Angelova Plamena, Traitcheva Nelly, Berg Hermann
Synergisms Of Electric Or Electromagnetic Fields And Photodynamic Effects Induce Apoptosis And Necrosis Of Cancer Cells, Radeva Maria, Lambrera Maya, Angelova Plamena, Traitcheva Nelly, Berg Hermann
Journal of Electrochemistry
Weak pulsating sinusoidal electromagnetic fields (PEMF) have been applied to change membrane permeation and induction of apoptosis (necrosis). In the case of suspension of human cancer cells U-937 and K-562 inside of Helmholtz-coils the amplitude of PEMF B=10 and at 39mT (at 50 Hz) was combined gradually with the cytotoxic agent actinomycin-C on one hand with its novel photodynamic activity on the other. Depending on temperature, pH-value and treatment time the necrosis of these cells was determined by means of trypan blue staining as well as the induced apoptosis by FACScan technique. Synergisms were discovered yielding high rates of cell …