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Design And Implementation Of Position-Encoded Microfluidic Microsphere-Trap Arrays, Xiaoxiao Xu

All Theses and Dissertations (ETDs)

Microarray devices are useful for detecting and analyzing biological targets, such as DNAs, mRNAs, proteins, etc. Applications of microarrays range from fundamental research to clinical diagnostics and drug discovery. In this dissertation, we consider a microsphere array device with predetermined positions of the microspheres. The microspheres are conjugate on their surfaces with molecular probes to capture the targets, and the targets are identified by the microspheres' positions. We implement the microsphere arrays by employing microfluidic technology and a hydrodynamic trapping mechanism. We call our device microfluidic microsphere-trap arrays. To fully realize the potential of the device in biomedical applications, we …