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Role Of Ahr Ligands In Immune Modulation To Suppress Inflammation Through The Regulation Of Microrna And Gut Microbiome, Osama Azeldeen Abdulla
Role Of Ahr Ligands In Immune Modulation To Suppress Inflammation Through The Regulation Of Microrna And Gut Microbiome, Osama Azeldeen Abdulla
Theses and Dissertations
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor and an environmental sensor that is highly conserved evolutionarily. It was first discovered in the early 1970s for its ability to bind with high affinity to 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), an environmental pollutant and induce a xenobiotic-metabolizing enzyme known as aryl hydrocarbon hydroxylase (AHH). AhR was shown to regulate TCDD-mediated toxicity against a variety of tissues including the immune system. More recently, AhR has been characterized as key regulator of the immune system, specifically the differentiation of T cells. Also, several AhR ligands have been characterized in addition to TCDD such as …