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Engineering Commons™

Open Access. Powered by Scholars. Published by Universities.®

Electrical and Computer Engineering

University of Massachusetts Amherst

Selected Works

2008

Multiphoton processes

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Design And Demonstration Of A Small-Animal Up-Conversion Imager, Christopher Salthouse, Scott Hildebrand, Ralph Weissleder, Umar Mahmood Dec 2008

Design And Demonstration Of A Small-Animal Up-Conversion Imager, Christopher Salthouse, Scott Hildebrand, Ralph Weissleder, Umar Mahmood

Christopher Salthouse

This first small-animal up-conversion imager (SAUCI) was developed and used for in-vivo imaging of up-converting nanoparticles (UCNs.) Unlike traditional fluorophores, UCNs absorb multiple lower-energy photons and emit a single higher-energy photon. This unique physical process makes it possible to image deeper into tissue with lower background signals. In vivo imaging of particle accumulation in the liver was demonstrated following intravenous injection of particles.

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