Engineering Commons^™

Quadrupoles For Remote Electrostimulation Incorporating Bipolar Cancellation, Shu Xiao, Ryo Yamada, Carol Zhou

Bioelectrics Publications

Introduction: A method that utilizes nanosecond bipolar cancellation (BPC) near a quadrupole electrodes to suppress a biological response but cancels the distal BPC at the quadrupole center, i.e., cancellation of cancellation (CANCAN), may allow for a remote focused stimulation at the quadrupole center.

Objectives: The primary object of this study was to outline the requirement of the CANCAN implementation and select an effective quadrupole configuration.

Results: We have studied three quadrupole electrode configurations, a rod quadrupole, a plate quadrupole (Plate-Q), and a resistor quadrupole. The pulse shapes of electric fields include monophasic pulses, cancellation pulses, and additive pulses. The Plate-Q …

Ablation Of Myocardial Tissue With Nanosecond Pulsed Electric Fields, Fei Xie, Frency Varghese, Andrei G. Pakhomov, Iurii Semenov, Shu Xiao, Jonathan Philpott, Christian Zemlin

Bioelectrics Publications

Background

Ablation of cardiac tissue is an essential tool for the treatment of arrhythmias, particularly of atrial fibrillation, atrial flutter, and ventricular tachycardia. Current ablation technologies suffer from substantial recurrence rates, thermal side effects, and long procedure times. We demonstrate that ablation with nanosecond pulsed electric fields (nsPEFs) can potentially overcome these limitations.

Methods

We used optical mapping to monitor electrical activity in Langendorff-perfused New Zealand rabbit hearts (n = 12). We repeatedly inserted two shock electrodes, spaced 2–4 mm apart, into the ventricles (through the entire wall) and applied nanosecond pulsed electric fields (nsPEF) (5–20 kV/cm, 350 ns duration, …

Microscopic Analysis For Water Stressed By High Electric Fields In The Prebreakdown Regime, R. P. Joshi, J. Qian, K. H. Schoenbach, E. Schamiloglu

Bioelectrics Publications

Analysis of the electrical double layer at the electrode-water interface for voltages close to the breakdown point has been carried out based on a static, Monte Carlo approach. It is shown that strong dipole realignment, ion-ion correlation, and finite-size effects can greatly modify the electric fields and local permittivity (hence, leading to optical structure) at the electrode interface. Dramatic enhancements of Schottky injection, providing a source for electronic controlled breakdown, are possible. It is also shown that large pressures associated with the Maxwell stress tensor would be created at the electrode boundaries. Our results depend on the ionic density, and …

Electric Field Mapping System With Nanosecond Temporal Rosolution, F. E. Peterkin, R. Block, K. H. Schoenbach

Bioelectrics Publications

The electric field dependence of the absorption coefficient in semi‐insulating GaAs at the absorption edge was measured in a high‐voltage pulsed experiment. Pulse duration was kept below 50 ns in order to avoid thermal effects. A GaAs laser diode was used as a probe light source with wavelength varied from 902 to 911 nm. For fields up to 40 kV/cm the absorption coefficient increased from 3 to 17 cm⁻¹ at 902 nm, with smaller absolute increases evident at the longer wavelengths. Calculation from theory was consistent with this behavior. The spatial variation of the electric field was also recorded …

Temporal Development Of Electric Field Structures In Photoconductive Gaas Switches, K. H. Schoenbach, J. S. Kenney, F.E. Peterkin, R. J. Allen

Bioelectrics Publications

The temporal development of the electric field distribution in semi‐insulating GaAs photoconductive switches operated in the linear and lock‐on mode has been studied. The field structure was obtained by recording a change in the absorption pattern of the switch due to the Franz–Keldysh effect at a wavelength near the band edge of GaAs. In the linear mode, a high field layer develops at the cathode contact after laser activation. With increasing applied voltage, domainlike structures become visible in the anode region and the switch transits into the lock‐on state, a permanent filamentary electrical discharge. Calibration measurements show the field intensity …

Electric Field Induced Emission As A Diagnostic Tool For Measurement Of Local Electric Field Strengths, A. N. Dharamsi, K. H. Schoenbach

Bioelectrics Publications

The phenomenon of electric field induced (EFI) emission is examined in several diatomic and polyatomic molecules. The possibility of using this phenomenon as a diagnostic tool to measure, nonintrusively, the strength and direction of local electric fields in plasmas is discussed. An estimate of the EFI signal emitted in a typical application plasma is given. This yields a lower bound on the detector sensitivity necessary to exploit EFI emission in practical applications. It is concluded that, at present, the EFI signal could be measured by some very sensitive infrared detection schemes available. Current progress in infrared detector technology, if maintained, …