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Improved Single Molecule Detection Platform Using A Buried Arrow Design, Thomas Allen Wall
Improved Single Molecule Detection Platform Using A Buried Arrow Design, Thomas Allen Wall
Theses and Dissertations
As the microelectronics industry pushes microfabrication processes further, the lab-on-a-chip field has continued to piggy-back off the industry's fabrication capabilities with the goal of producing total chemical and biological systems on small chip-size platforms. One important function of such systems is the ability to perform single molecule detection. There are currently many methods being researched for performing single molecule detection, both macro and micro in scale. This dissertation focuses on an optofluidic, lab-on-a-chip platform called the ARROW biosensor, which possesses several advantages over macro-scale single molecule detection platforms. These advantages include an amplification-free detection scheme, cheap parallel fabrication techniques, rapid …
Preserving Optical Confinement In Pecvd Sio2 Waveguides By Control Of Thin-Film Stress, Steven Jay Hammon
Preserving Optical Confinement In Pecvd Sio2 Waveguides By Control Of Thin-Film Stress, Steven Jay Hammon
Theses and Dissertations
Researchers at Brigham Young University (BYU) have developed an optical biosensor that can quickly analyze a sample to detect any type of nucleic acid based organism, such as viruses or bacteria. The biosensor's reliability over time is compromised due to water absorbing into the SiO2 waveguides of the chip. It was hypothesized that keeping the thin-film stress of the waveguides close to zero would slow or stop water absorption from occurring. Completion of this thin-film study relied upon a new plasma enhanced chemical vapor deposition (PECVD) machine and a new 3-D optical profilometer, both of which were installed in …