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Electrical and Computer Engineering
University of Nebraska - Lincoln
Department of Electrical and Computer Engineering: Faculty Publications
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Higher C-Reactive Protein Levels Predict Postoperative Delirium In Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study, Simon T. Dillon, Sarinnapha M. Vasunilashorn, Long Ngo, Hasan H. Otu, Sharon K. Inouye, Richard N. Jones, David C. Alsop, George A. Kuchel, Eran D. Metzger, Steven E. Arnold, Edward R. Marcantonio, Towia A. Libermann
Higher C-Reactive Protein Levels Predict Postoperative Delirium In Older Patients Undergoing Major Elective Surgery: A Longitudinal Nested Case-Control Study, Simon T. Dillon, Sarinnapha M. Vasunilashorn, Long Ngo, Hasan H. Otu, Sharon K. Inouye, Richard N. Jones, David C. Alsop, George A. Kuchel, Eran D. Metzger, Steven E. Arnold, Edward R. Marcantonio, Towia A. Libermann
Department of Electrical and Computer Engineering: Faculty Publications
Background—Delirium is a common, morbid, and costly postoperative complication.. We aimed to identify blood-based postoperative delirium markers in a nested case control study of older surgical patients using a proteomics approach followed by enzyme-linked immunosorbent assay (ELISA) validation.
Methods and Materials—The Successful Aging after Elective Surgery Study enrolled dementia-free adults age ≥70 undergoing major scheduled non-cardiac surgery (N=566; 24% delirium). Plasma was collected at 4 timepoints: preoperatively (PREOP), post-anesthesia care unit (PACU), postoperative day 2 (POD2) and 1 month follow-up (PO1MO). Matched pairs were selected for the independent discovery (39 pairs) and replication cohorts (36 pairs), which were …