Engineering Commons^™

Large Genomes Assembly Using Mapreduce Framework, Yuehua Zhang

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Knowing the genome sequence of an organism is the essential step toward understanding its genomic and genetic characteristics. Currently, whole genome shotgun (WGS) sequencing is the most widely used genome sequencing technique to determine the entire DNA sequence of an organism. Recent advances in next-generation sequencing (NGS) techniques have enabled biologists to generate large DNA sequences in a high-throughput and low-cost way. However, the assembly of NGS reads faces significant challenges due to short reads and an enormously high volume of data. Despite recent progress in genome assembly, current NGS assemblers cannot generate high-quality results or efficiently handle large genomes …

The Importance Of Hand Motions For Communication And Interaction In Virtual Reality, Alex Adkins

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Virtual reality (VR) is a growing method of communication and play. Recent advances have enabled hand-tracking technologies for consumer VR headsets, allowing virtual hands to mimic a user's real hand movements in real-time. A growing number of users now utilize hand-tracking when using VR to manipulate objects or to create gestures when interacting with others. As VR grows as a tool and communication platform, it is important to understand how the rising prevalence of hand-tracking technology might affect users' experiences.

The goal of this dissertation is to investigate, through a series of experiments, how using hand motions in VR influences …

Modeling, Control And Estimation Of Reconfigurable Cable Driven Parallel Robots, Adhiti Raman Thothathri

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The motivation for this thesis was to develop a cable-driven parallel robot (CDPR) as part of a two-part robotic device for concrete 3D printing. This research addresses specific research questions in this domain, chiefly, to present advantages offered by the addition of kinematic redundancies to CDPRs. Due to the natural actuation redundancy present in a fully constrained CDPR, the addition of internal mobility offers complex challenges in modeling and control that are not often encountered in literature.

This work presents a systematic analysis of modeling such kinematic redundancies through the application of reciprocal screw theory (RST) and Lie algebra while …

Scalable Data-Driven Predictive Modeling And Analytics For Cho Process Development Optimization, Sarah Mbiki

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In 1982, the FDA approved the first recombinant therapeutic protein, and since then, the biopharmaceutical industry has continued to develop innovative and highly effective biological drugs for various illnesses¹. These drugs are produced using host organisms that are modified to hold the genetic encoding of the targeted protein¹. Of the many host organisms, Chinese hamster ovary (CHO) cells are often used due to capability to perform posttranslational modification (PTM): which allows human-like synthesis of proteins unlikely to invoke immunogenicity in humans ^1,2.

Despite all the positive attributes, many challenges are associated with CHO cell cultures, …

Multi-Robot Symbolic Task And Motion Planning Leveraging Human Trust Models: Theory And Applications, Huanfei Zheng

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Multi-robot systems (MRS) can accomplish more complex tasks with two or more robots and have produced a broad set of applications. The presence of a human operator in an MRS can guarantee the safety of the task performing, but the human operators can be subject to heavier stress and cognitive workload in collaboration with the MRS than the single robot. It is significant for the MRS to have the provable correct task and motion planning solution for a complex task. That can reduce the human workload during supervising the task and improve the reliability of human-MRS collaboration. This dissertation relies …

Snap : A Software-Defined & Named-Data Oriented Publish-Subscribe Framework For Emerging Wireless Application Systems, Manveen Kaur

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The evolution of Cyber-Physical Systems (CPSs) has given rise to an emergent class of CPSs defined by ad-hoc wireless connectivity, mobility, and resource constraints in computation, memory, communications, and battery power. These systems are expected to fulfill essential roles in critical infrastructure sectors. Vehicular Ad-Hoc Network (VANET) and a swarm of Unmanned Aerial Vehicles (UAV swarm) are examples of such systems. The significant utility of these systems, coupled with their economic viability, is a crucial indicator of their anticipated growth in the future. Typically, the tasks assigned to these systems have strict Quality-of-Service (QoS) requirements and require sensing, perception, and …

Algorithm Optimization And Hardware Acceleration For Machine Learning Applications On Low-Energy Systems, Jianchi Sun

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Machine learning (ML) has been extensively employed for strategy optimization, decision making, data classification, etc. While ML shows great triumph in its application field, the increasing complexity of the learning models introduces neoteric challenges to the ML system designs. On the one hand, the applications of ML on resource-restricted terminals, like mobile computing and IoT devices, are prevented by the high computational complexity and memory requirement. On the other hand, the massive parameter quantity for the modern ML models appends extra demands on the system's I/O speed and memory size. This dissertation investigates feasible solutions for those challenges with software-hardware …

The Development Of Tigra: A Zero Latency Interface For Accelerator Communication In Risc-V Processors, Wesley Brad Green

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Field programmable gate arrays (FPGA) give developers the ability to design application specific hardware by means of software, providing a method of accelerating algorithms with higher power efficiency when compared to CPU or GPU accelerated applications. FPGA accelerated applications tend to follow either a loosely coupled or tightly coupled design. Loosely coupled designs often use OpenCL to utilize the FPGA as an accelerator much like a GPU, which provides a simplifed design flow with the trade-off of increased overhead and latency due to bus communication. Tightly coupled designs modify an existing CPU to introduce instruction set extensions to provide a …

Digitalization Of Construction Project Requirements Using Natural Language Processing (Nlp) Techniques, Fahad Ul Hassan

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Contract documents are a critical legal component of a construction project that specify all wishes and expectations of the owner toward the design, construction, and handover of a project. A single contract package, especially of a design-build (DB) project, comprises hundreds of documents including thousands of requirements. Precise comprehension and management of the requirements are critical to ensure that all important explicit and implicit requirements of the project scope are captured, managed, and completed. Since requirements are mainly written in a natural human language, the current manual methods impose a significant burden on practitioners to process and restructure them into …

Control, Decision-Making, And Learning Approaches For Connected And Autonomous Driving Systems With Humans-In-The-Loop, Fangjian Li

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By virtue of vehicular connectivity and automation, the vehicle becomes increasingly intelligent and self-driving capable. However, no matter what automation level the vehicle can achieve, humans will still be in the loop despite their roles. First, considering the manual driving car as a disturbance to the connected and autonomous vehicles (CAVs), a novel string stability is proposed for mixed traffic platoons consisting of both autonomous and manual driving cars to guarantee acceptable motion fluctuation and platoon safety. Furthermore, humans are naturally considered as the rider in the passenger vehicle. A human-centered cooperative adaptive cruise control (CACC) is designed to improve …