Engineering Commons^™

Bijels Made By Solvent Transfer Induced Phase Separation: Formation Principles And Transport, Stephen Boakye-Ansah

Theses and Dissertations

Bijels are made of non-equilibrium particle-stabilized emulsions with a bicontinuous arrangement of the constituent fluid phases. They spontaneously form through arrested spinodal decomposition in mixtures of partially miscible liquids and neutrally wetting colloidal particles. Soon after their discovery over 10 years ago, Prof. Mike Cates, Lucasian Professor of Mathematics, predicted their future use as continuously operated cross-flow reactors for chemical reactions between immiscible reactants.

Towards this goal, work in this thesis focuses on designing bijels via Solvent Transfer Induced Phase Separation (STrIPS) for microfluidic transport applications. Structure-function relationships of STrIPS bijels stabilized by silane functionalized nanoparticles are developed. In-situ surfactant …

Formulation And Validation Of Nanoparticle Controlled Delivery For Chemotherapeutic Drug Products, Shani L. Levit

Theses and Dissertations

Taxol, a formulation of paclitaxel (PTX), is one of the most widely used anticancer drugs, particularly for treating recurring ovarian carcinomas following surgery. Clinically, PTX is used in combination with other drugs such as lapatinib (LAP) to increase treatment efficacy. Delivering drug combinations with nanoparticles has the potential to improve chemotherapy outcomes. In this study, we use Flash NanoPrecipitation, a rapid, scalable process to encapsulate weakly hydrophobic drugs (logP in vitro. Encapsulating either PTX or LAP into nanoparticles increases drug potency. When PTX and LAP are co-loaded in the same nanoparticle, they have a synergistic effect that is greater than …