Engineering Commons^™

Synthetic Materials With Redox-Triggers For Imaging And Drug Delivery, Jungeun Bae

Electronic Theses and Dissertations

Synthetic materials embedded with stimuli-responsive cleavable bonds have been extensively utilized for the development of site-targeted drug delivery system and selective imaging reporters. We developed stimuli-sensitive materials with two different redox switches including trimethyl-locked quinone propionic acid and nitrobenzyl moieties. Novel redox-sensitive polymeric nanoparticles and micelles were prepared from a synthesized monomer containing trimethyl-locked quinone propionic acid as a redox trigger. A hydrophobic cancer drug, Paclitaxel, was incorporated into the redox-responsive polymeric nanoparticles and micelles prepared from the synthesize polymers. The effect of redox stress on the nanoparticles and micelles was evaluated with a chemical reductant, sodium dithionite demonstrating that …