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Articles 1 - 9 of 9
Full-Text Articles in Engineering
Improving Thermodynamic Consistency Among Vapor Pressure, Heat Of Vaporization, And Liquid And Ideal Gas Heat Capacities, Joseph Wallace Hogge
Improving Thermodynamic Consistency Among Vapor Pressure, Heat Of Vaporization, And Liquid And Ideal Gas Heat Capacities, Joseph Wallace Hogge
Theses and Dissertations
Vapor pressure (Pvap), heat of vaporization (ΔHvap), liquid heat capacity (Cpl), and ideal gas heat capacity (Cpig) are important properties for process design and optimization. This work focuses on improving the thermodynamic consistency and accuracy of the aforementioned properties since these can drastically affect the reliability, safety, and profitability of chemical processes. They can be measured for pure organic compounds from the triple point, through the normal boiling point, and up to the critical point. Additionally, ΔHvap is proportional to the derivative of vapor …
A Molecular Simulation Study Of Antibody-Antigen Interactions On Surfaces For The Rational Design Of Next-Generation Antibody Microarrays, Derek B. Bush
Theses and Dissertations
Antibody microarrays constitute a next-generation sensing platform that has the potential to revolutionize the way that molecular detection is conducted in many scientific fields. Unfortunately, current technologies have not found mainstream use because of reliability problems that undermine trust in their results. Although several factors are involved, it is believed that undesirable protein interactions with the array surface are a fundamental source of problems where little detail about the molecular-level biophysics are known. A better understanding of antibody stability and antibody-antigen binding on the array surface is needed to improve microarray technology. Despite the availability of many laboratory methods for …
Cell-Free Synthesis Of Proteins With Unnatural Amino Acids: Exploring Fitness Landscapes, Engineering Membrane Proteins And Expanding The Genetic Code, Song Min Schinn
Cell-Free Synthesis Of Proteins With Unnatural Amino Acids: Exploring Fitness Landscapes, Engineering Membrane Proteins And Expanding The Genetic Code, Song Min Schinn
Theses and Dissertations
Unnatural amino acids (uAA) expand the structural and functional possibilities of proteins. Numerous previous studies have demonstrated uAA as a powerful tool for protein engineering, but challenges also remain. Three notable such challenges include: (1) the fitness of uAA-incorporated proteins are difficult to predict and time-consuming to screen with conventional methods, (2) uAA incorporation in difficult-to-express proteins (e.g. membrane proteins such as G-protein coupled receptors) remain challenging, and (3) the incorporation of multiple types of uAA are still limited. In response, we pose cell-free protein synthesis (CFPS), a rapid and versatile in vitro expression system, as a platform to explore …
Particle Deposition Behavior From Coal-Derived Syngas In Gas Turbines At Modern Turbine Inlet Temperatures, Robert Laycock
Particle Deposition Behavior From Coal-Derived Syngas In Gas Turbines At Modern Turbine Inlet Temperatures, Robert Laycock
Theses and Dissertations
Certain types of fuel used for combustion in land-based gas turbines can contain traces of ash when introduced into a gas turbine. Examples include synfuel, from the gasification of coal, and heavy fuel oil. When these ash particles travel through the hot gas path of the gas turbine they can deposit on turbine vanes and blades. As deposits grow, they can reduce turbine efficiency and damage turbine hardware. As turbine inlet temperatures increase, ash deposition rates increase as well.Experiments were conducted in the Turbine Accelerated Deposition Facility (TADF) at Brigham Young University to better understand ash deposition behavior at modern …
A Comprehensive Coal Conversion Model Extended To Oxy-Coal Conditions, Troy Michael Holland
A Comprehensive Coal Conversion Model Extended To Oxy-Coal Conditions, Troy Michael Holland
Theses and Dissertations
CFD simulations are valuable tools in evaluating and deploying oxy-fuel and other carbon capture technologies either as retrofit technologies or for new construction. However, accurate predictive simulations require physically realistic submodels with low computational requirements. In particular, comprehensive char oxidation and gasification models have been developed that describe multiple reaction and diffusion processes. This work extends a comprehensive char conversion code (the Carbon Conversion Kinetics or CCK model), which treats surface oxidation and gasification reactions as well as processes such as film diffusion, pore diffusion, ash encapsulation, and annealing. In this work, the CCK model was thoroughly investigated with a …
Metallization Of Self-Assembled Dna Templates For Electronic Circuit Fabrication, Bibek Uprety
Metallization Of Self-Assembled Dna Templates For Electronic Circuit Fabrication, Bibek Uprety
Theses and Dissertations
This work examines the deposition of metallic and semiconductor elements onto self-assembled DNA templates for the fabrication of nanodevices. Biological molecules like DNA can self-assemble into a variety of complex 2-D and 3-D architectures without the need for expensive patterning tools. In addition, self-assembled DNA templates can be designed to controllably place functional nanomaterials with molecular precision. These characteristics make DNA an attractive template for fabricating electronic circuits from biological molecules. However, electrically conductive structures are required for electronic applications. While metallized DNA nanostructures have been demonstrated, the ability to make thin, continuous wires that are electrically conductive still represents …
Multi-Fidelity Model Predictive Control Of Upstream Energy Production Processes, Ammon Nephi Eaton
Multi-Fidelity Model Predictive Control Of Upstream Energy Production Processes, Ammon Nephi Eaton
Theses and Dissertations
Increasing worldwide demand for petroleum motivates greater efficiency, safety, and environmental responsibility in upstream oil and gas processes. The objective of this research is to improve these areas with advanced control methods. This work develops the integration of optimal control methods including model predictive control, moving horizon estimation, high fidelity simulators, and switched control techniques applied to subsea riser slugging and managed pressure drilling. A subsea riser slugging model predictive controller eliminates persistent offset and decreases settling time by 5% compared to a traditional PID controller. A sensitivity analysis shows the effect of riser base pressure sensor location on controller …
Decellularization And Recellularization Processes For Whole Porcine Kidneys, Nafiseh Poornejad
Decellularization And Recellularization Processes For Whole Porcine Kidneys, Nafiseh Poornejad
Theses and Dissertations
Concern over kidney disease has increased dramatically in recent years within the medical community. It is estimated that approximately one in fifteen Americans, nearly 20 million people, experience chronic kidney disease with most of those diagnosed progressing to kidney failure. The ultimate treatment available for end stage renal failure is whole kidney transplantation. However, there are very few kidneys available for patients to receive and those patients who are fortunate enough to receive an organ must remain on immunosuppressive medication for the remainder of their lives. The United States Department of Health & Human Services have reported that 18 people …
Engineering Cell-Free Protein Synthesis Technology For Codon Reassignment, Biotherapeutics Production Using Just-Add-Water System, And Biosensing Endocrine Disrupting Compounds, Sayed Mohammad Salehi
Engineering Cell-Free Protein Synthesis Technology For Codon Reassignment, Biotherapeutics Production Using Just-Add-Water System, And Biosensing Endocrine Disrupting Compounds, Sayed Mohammad Salehi
Theses and Dissertations
Cell-free protein synthesis is an emerging technology that has many applications. The open nature of this system makes it a compelling technology that can be manipulated to answer many needs that are unavailable in other systems. This dissertation reports on engineering this technology for: 1) sense codon emancipation for incorporation of multiple unnatural amino acids; 2) expressing a hard-to-express anticancer biotherapeutic and introducing a just-add-water system; 3) a biosensing ligand that interacts with nuclear hormone receptors. Emancipating sense codons toward a minimized genetic code is of significant interest to science and engineering. A promising approach to sense codon emancipation is …