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Intelligen Superpro Designer Files For Economic Simulation Of Batch And Continuous Aqueous Two-Phase Purification For Viral Products, Natalie Nold, Eric Pearson, Caryn L. Heldt

Michigan Tech Research Data

Vaccine manufacturing strategies that lower capital and production costs could improve vaccine access by reducing the cost per dose and encouraging localized manufacturing. Continuous processing is increasingly utilized to drive lower costs in biological manufacturing by requiring fewer capital and operating resources. Aqueous two-phase systems (ATPS) are a liquid-liquid extraction technique that enables continuous processing for viral vectors. To date, no economic comparison between viral vector purifications using traditional methods and ATPS has been published. In this work, economic simulations of traditional chromatography-based virus manufacturing were compared to simulations of ATPS-based virus manufacturing for the same product output in both …