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Development And Validation Of A Smartphone-Based Near-Infrared Optical Imaging Device To Measure Physiological Changes In-Vivo, Kacie Kaile, Anuradha Godavarty
Development And Validation Of A Smartphone-Based Near-Infrared Optical Imaging Device To Measure Physiological Changes In-Vivo, Kacie Kaile, Anuradha Godavarty
Department of Biomedical Engineering Faculty Publications
Smartphone-based technologies for medical imaging purposes are limited, especially when it involves the measurement of physiological information of the tissues. Herein, a smartphone-based near-infrared (NIR) imaging device was developed to measure physiological changes in tissues across a wide area and without contact. A custom attachment containing multiple multi-wavelength LED light sources (690, 800, and 840 nm; and <4 mW of optical power per LED), source driver, and optical filters and lenses was clipped onto a smartphone that served as the detector during data acquisition. The ability of the device to measure physiological changes was validated via occlusion studies on control subjects. Noise removal techniques using singular value decomposition algorithms effectively removed surface noise and distinctly differentiated the physiological changes in response to occlusion. In the long term, the developed smartphone-based NIR imaging device with capabilities to capture physiological changes will be a great low-cost alternative for clinicians and eventually for patients with chronic ulcers and bed sores, and/or in pre-screening for potential ulcers in diabetic subjects.
Optical Phantoms For Biomedical Polarimetry: A Review, Joseph Chue-Sang, Mariacarla Gonzalez, Angie Pierre, Megan Laughrey, Ilyas Saytashev, Tatiana Novikova, Jessica C. Ramella-Roman
Optical Phantoms For Biomedical Polarimetry: A Review, Joseph Chue-Sang, Mariacarla Gonzalez, Angie Pierre, Megan Laughrey, Ilyas Saytashev, Tatiana Novikova, Jessica C. Ramella-Roman
Department of Biomedical Engineering Faculty Publications
Calibration, quantification, and standardization of the polarimetric instrumentation, as well as interpretation and understanding of the obtained data, require the development and use of well-calibrated phantoms and standards. We reviewed the status of tissue phantoms for a variety of applications in polarimetry; more than 500 papers are considered. We divided the phantoms into five groups according to their origin (biological/nonbiological) and fundamental polarimetric properties of retardation, depolarization, and diattenuation. We found that, while biological media are generally depolarizing, retarding, and diattenuating, only one of all the phantoms reviewed incorporated all these properties, and few considered at least combined retardation and …