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Articles 1 - 12 of 12
Full-Text Articles in Engineering
The Effect Of Phase-Separated Microstructures On Cell Migration In 3d Dextran Hydrogels, Jenifer Sidhwa
The Effect Of Phase-Separated Microstructures On Cell Migration In 3d Dextran Hydrogels, Jenifer Sidhwa
Honors Theses and Capstones
No abstract provided.
Non-Invasive Monitoring Device For Early Detection Of Breast Cancer Related Lymphedema, Amy Prendergast
Non-Invasive Monitoring Device For Early Detection Of Breast Cancer Related Lymphedema, Amy Prendergast
Honors Theses and Capstones
Breast Cancer Related Lymphedema (BCRL) is a common co-morbidity in cancer survivors following neoadjuvant therapies such as chemotherapy, radiation, and/or surgery. It is brought about by the disruption in the lymphatic system (think lymph node biopsy) that leads to a buildup of lymphatic fluid in the arm. Current diagnostic strategies for this condition are merely retroactive, and fairly limited in the parameters that are examined to ensure patient well-being long term. We hypothesize that with an approach that mimics bioimpedance spectroscopy analysis, we will be able to provide a clinical support tool that would better determine early stages of lymphedema …
Engineering Thermostable Regulators For Inducible Gene Expression In Thermophiles, Connor M. Joyce
Engineering Thermostable Regulators For Inducible Gene Expression In Thermophiles, Connor M. Joyce
Honors Theses and Capstones
Thermophilic bacteria have attracted research interest due to their ability to grow at high temperatures ranging from 45 °C to 75 °C with some extreme thermophiles able to survive nearly boiling temperatures. They are valuable sources of thermostable biocatalysts and many have great potential as industrial hosts for biofuel production because fermentation at high temperatures has advantages such as reduced processing costs and lower risk of contamination compared with mesophilic bacteria. For example, some Geobacillus species has been shown to have high solvent tolerance, making them good candidates as host for alcohol production. To develop them as industrial hosts, large …
Injectable Gelatin-Silk Fibroin Composite Hydrogels For In Situ Cell Encapsulation, Ryann D. Boudreau
Injectable Gelatin-Silk Fibroin Composite Hydrogels For In Situ Cell Encapsulation, Ryann D. Boudreau
Honors Theses and Capstones
Hydrogels are widely used tools for tissue engineering and regenerative medicine. Characterized as biofunctional, water-based polymer matrices with tunable mechanical properties, hydrogels have promising but limited applications in biomedical engineering, due to poor and static matrix strength. Here we plan to rectify this issue by introducing a new hydrogel made from a composite of gelatin and silk fibroin crosslinked by microbial transglutaminase (mTG) instantly and beta sheet formation gradually, respectively. This interpenetrating network (IPN) shows enhanced mechanical stiffness and strength compared to gelatin hydrogels, and is capable of encapsulating human cells with high viability demonstrated by the encapsulation of human …
Eeg And Emg Sensorimotor Measurements To Assess Proprioception Following Acl Reconstruction, Teagan Frances Northrup
Eeg And Emg Sensorimotor Measurements To Assess Proprioception Following Acl Reconstruction, Teagan Frances Northrup
Honors Theses and Capstones
The Anterior Cruciate Ligament (ACL) is the primary source of rotational stability in the knee by preventing the tibia from sliding in front of the femur. When the ACL is torn, it typically must be repaired through reconstructive surgery which results in proprioceptive deficiencies in the knee. Proprioception plays an important role in understanding where one’s knee is in space, sensing movement and reacting accordingly. This study examines an alternative method of measuring proprioceptive responses to a stimulus (motion) by using electromyogram (EMG) and electroencephalogram (EEG) signals to observe muscle and brain activity. Two participants (one with an ACL reconstruction …
Electrochemical And Spectroscopic Study Of Peptide-Template Melanins, Daniel Courter, Olivia Rossi, Zhen Tian
Electrochemical And Spectroscopic Study Of Peptide-Template Melanins, Daniel Courter, Olivia Rossi, Zhen Tian
Honors Theses and Capstones
Melanins are organic polymers made up of 5,6-dihydroxyindole carboxylic acid (DHICA) and 5,6-dihydroxyindole (DHI). Biochemical systems synthesize melanins through a complex reaction pathway. Previous research exhibited that naturally-occurring melanins (NatMel) and their synthetic analogues (SynMel) can potentially serve as electrode materials for aqueous charge storage devices. Small surface area creates technical challenges for these melanins as charge storage materials. This research herein demonstrates that the structure of melanins can affect the charge storage capacities of monovalent Na+cations and divalent Mg2+ cations. 2-D sheet-like peptide melanins (PepMel) were synthesized into tripeptides consisting of aspartic acid (D), phenylalanine (F), …
Developing Genetic Tools For Geobacillus, Brittany Artale
Developing Genetic Tools For Geobacillus, Brittany Artale
Honors Theses and Capstones
Bacillus and Geobacillus are the primary bacterium used in biotechnology industries due to their ability to excrete extracellular materials such as proteins, enzymes and other byproducts. Bacillus subtilis, has a well-characterized competence machinery, giving way to characterized genetic tools. However, a significant problem associated with working with Bacillus is the regulation of endospore formation. An alternative to Bacillus is Geobacillus, a thermophilic bacterium. Thermophiles offer significant advantages over other bacteria as host organisms in biofuel, bioremediation, and biocatalyst processes. However, the genetic tools and competency associated with Geobacillus is still unknown. Through, genetic engineering the ability …
Can We Engineer Our Way To Good Health?, Russell T. Carr
Can We Engineer Our Way To Good Health?, Russell T. Carr
The University Dialogue
No abstract provided.
Bayer Ag V. Housey Pharmaceuticals: Protection For Biotechnological Research Tools Under Section 271(G) Found Wanting, Matthew Barthalow
Bayer Ag V. Housey Pharmaceuticals: Protection For Biotechnological Research Tools Under Section 271(G) Found Wanting, Matthew Barthalow
The University of New Hampshire Law Review
[Excerpt] "Research tools, a subset of biotechnological inventions protected by process patents, are “tools that scientists use in the laboratory, including cell lines, monoclonal antibodies, reagents, animal models, growth factors, combinatorial chemistry and DNA libraries, clones and cloning tools (such as PCR), methods, laboratory equipment and machines.” Many companies base their business models on the ability to find pharmaceutical products using their proprietary drug discovery research tools. Research tools used for drug discovery ‘include bioinformatic methods for identifying the interaction of certain proteins and their association with disease, methods for confirming protein targets, screening assays to identify molecules active against …
Overview Of Federal Technology Transfer, Lawrence Rudolph
Overview Of Federal Technology Transfer, Lawrence Rudolph
RISK: Health, Safety & Environment (1990-2002)
Mr. Rudolph reviews approximately thirteen years of legal and political developments that have contributed to laws governing the extent to which private firms may secure rights in technology at least partly developed with federal funds.
Technology Transfer: A View From The Trenches, Harvey Drucker
Technology Transfer: A View From The Trenches, Harvey Drucker
RISK: Health, Safety & Environment (1990-2002)
Dr. Drucker, who has lab-wide responsibility for technology transfer at Argonne National Laboratory, argues that transferring rights in discoveries made through tax supported research to private entities can contribute to public welfare in many ways.
Informed Consent And The Investigational Use Of Medical Devices: A Comparison Of Common Law Duties With Those Imposed On Researchers Under Section 520(G) Of The Medical Device Amendments Of 1976, Thomas G. Field Jr., Dominic Piacenza
Informed Consent And The Investigational Use Of Medical Devices: A Comparison Of Common Law Duties With Those Imposed On Researchers Under Section 520(G) Of The Medical Device Amendments Of 1976, Thomas G. Field Jr., Dominic Piacenza
Law Faculty Scholarship
This paper will deal with with exemption granted [under the Medical Device Amendments Act of 1976] for the investigational use of devices subject to premarket testing, and more particularly, with the obligation of an investigator seeking such exemption to secure an informed consent agreement from human subjects (or their representatives) under § 520(g)(3)(D) of the Act. It will also consider the relationship between the statutory obligation and that which might be imposed by the common law of negligence.