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Full-Text Articles in Engineering
Engineering Hydrogels For Delivery Of Therapeutic Proteins, Francesca Briggs, Daryn Browne
Engineering Hydrogels For Delivery Of Therapeutic Proteins, Francesca Briggs, Daryn Browne
Bioengineering Senior Theses
In this project, we investigate how innate hydrogel properties can be leveraged for controlled protein drug release platforms. Therapeutic proteins have many valuable applications within the medical field, however, professionals often face many obstacles with obtaining controlled drug release. This paper analyzes how the manipulation of hydrogel properties can improve protein drug release rates. We started these investigations by varying hydrogel concentrations since we saw that this affects the release of small molecules. Additionally, we wanted to see what the addition of a second hydrogel network would do to protein release rates. These experiments concluded that raising polymer concentrations and …
Polystyrene Microsphere And 5-Fluorouracil Release From Custom Designed Wound Dressing Films, Maryam Mobed-Miremadi, Raki Komarla Nagendra, Sujana Lakshmi Ramachandruni, Jason James Rook, Mallika Keralapura, Michel Goedert
Polystyrene Microsphere And 5-Fluorouracil Release From Custom Designed Wound Dressing Films, Maryam Mobed-Miremadi, Raki Komarla Nagendra, Sujana Lakshmi Ramachandruni, Jason James Rook, Mallika Keralapura, Michel Goedert
Bioengineering
Custom-designed wound dressing films of chitosan and alginate have been prepared by a casting/solvent evaporation method for hydrophobic therapeutic agent encapsulation. In this parametric study, the propylene glycol (PG) and calcium chloride (CaCl2) concentrations were varied for chitosan and alginate films, respectively. Mechanical and chemical inter-related responses under observations included thickness (th), elasticity (E), tensile strength (TS), sorption ability (S%) and kinetics of in-vitro drug release, specifically in terms of membrane time to burst (tB) and duration of release (tR). As shown by results of a one tailed t-test significance testing at the 95% confidence interval (α = …