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Full-Text Articles in Engineering
Effect Of Deferoxamine On Late Deaths Following Cpr In Rats, Charles F. Babbs, Sushil D. Kompala, Karl E. Blaho
Effect Of Deferoxamine On Late Deaths Following Cpr In Rats, Charles F. Babbs, Sushil D. Kompala, Karl E. Blaho
Weldon School of Biomedical Engineering Faculty Publications
The iron chelating agent deferoxamine was studied in an animal model as post-resuscitation therapy to prevent late deaths and brain damage following total circulatory arrest and resuscitation. Cardio-respiratory arrest was induced by injection of cold, 1% KC1 into the left ventricles of ketamine anesthetized rats pretreated with succinylcholine chloride, and by discontinuation of positive pressure ventilation. CPR was begun after six minutes, and animals with return of spontaneous circulation were entered into the study. Within five minutes after return of spontaneous circulation, treated animals received deferoxamine (50 mg/kg, IV). At ten days, 16 of 25 (64%) of treated animals had …
An Experimental Circulatory Arrest Model In The Rat To Evaluate Calcium Antagonists In Cerebral Resuscitation, Lawrence De Garavilla, Charles F. Babbs, Willis A. Tacker
An Experimental Circulatory Arrest Model In The Rat To Evaluate Calcium Antagonists In Cerebral Resuscitation, Lawrence De Garavilla, Charles F. Babbs, Willis A. Tacker
Weldon School of Biomedical Engineering Faculty Publications
A circulatory arrest model in the rat was developed for use in cerebral and cardiac resuscitation studies. Whole-body ischemia was produced for 8 to 18 minutes by arresting the heart with a cold potassium chloride cardioplegic solution. Following cardiopulmonary resuscitation, minimal, standardized intensive care was provided. As the duration of ischemia was increased from 8 to 18 minutes, survival immediately following resuscitation decreased from 100% to 25%, and survival at 48 hours after ischemia decreased from 80% to 0%. Thirty per cent of the rats recovering from 11 minutes of ischemia suffered motor seizures. Survival and the incidence of motor …
Effect Of Pentobarbital Anesthesia On Ventricular Defibrillation Threshold In Dogs, Charles F. Babbs
Effect Of Pentobarbital Anesthesia On Ventricular Defibrillation Threshold In Dogs, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
The effect of pentobarbital anesthesia upon the minimal voltage and current required for electrical ventricular defibrillation (the defibrillation threshold) was investigated in dogs. Threshold current, energy, and charge in five dogs averaged 2 per cent, 13 per cent, and 6 per cent less under surgical levels of pentobarbital anesthesia than thresholds in the same animals in the awake, unanesthetized state. In dogs given sufficient pentobarbital to produce apnea and supported by mechanical ventilation, threshold current, energy, and charge averaged 3 per cent, 17 per cent, and 2 per cent less than comparable awake values. These differences were far from statistically …