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Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold
Characterization Of Electrospun Dlplga Nanofibers For A Drug Delivery System For Intracranial Tumors And Avms, Kimberly A. Griswold
Theses
Electrospinning processes apply electric fields to a polymer solution in order to produce strands of polymer in the nanoscale range. These polymer fibers are manipulated for their porosity, high surface area, fineness and uniformity. In order to create the ideal drug delivery system for intracranial arteriovenous malformations (AVMs) and tumors, D, L poly-(lactice-poly-glycolide) (DLPLGA) nanofibers were electrospun in a tetrahydrofuran (THF) solvent. Three different concentration ratios of DLPLGA, 85/15, 80/20, and 75/25 were analyzed to obtain the prime base for drug annexation. 1 ,3-bis (2-chloroethyl)- 1 -nitrosourea (BCNU) was then codissolved with the DLPLGA nanofibers to form a homogenous solution, …