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Behavior Of Deformed Dermal Fibroblasts Seeded On A Silicon Membrane Under High Levels Of Strain, Laura Osorno
Behavior Of Deformed Dermal Fibroblasts Seeded On A Silicon Membrane Under High Levels Of Strain, Laura Osorno
Theses
The main objective of this thesis is to understand, from a molecular perspective, the morphological and functional abnormalities of human dermal fibroblasts as a response to deformation produced by a normal force that can lead to the potential formation of stretch marks in pregnant women, adolescents, and people with Cushing's syndrome. The main function of dermal fibroblasts is to produce the essential fibrous components of the extracellular matrix (ECM) of the skin.
In order to study the mechanism of stretch mark formation, neonatal human dermal fibroblasts were seeded on a silicon membrane for controlled deformation. Upon reaching a confluence of …