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Neural Differentiation Of Pluripotent Stem Cells And Applications To Micropatterned Agarose Hydrogel For Nerve Guidance, Jamila S. Gittens
Neural Differentiation Of Pluripotent Stem Cells And Applications To Micropatterned Agarose Hydrogel For Nerve Guidance, Jamila S. Gittens
Theses
Many central nervous system (CNS) disorders are attributable to damaged oligodendrocytes, the cells that form the myelin sheath of axons. An effective source of human oligodendrocytes is crucial, making pluripotent stem cells, such as embryonic stem (ES) cells, an attractive source for nerve tissue repair and regeneration due to their unlimited capacity for self-renewal and their ability to differentiate into all major cell lineages. Bioengineered 3-D hydrogel culture systems have the potential to elucidate mechanisms required for regeneration of CNS cells. The goals of this study are: (1) to investigate the effects of retinoic acid (RA), sonic hedgehog (shh) agonist, …